Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice

Abstract A growing body of evidence suggests a relationship between olfactory dysfunction and the pathogenesis of mental disorders. Our previous studies indicated that chronic nasal inflammation caused loss of olfactory sensory neurons and gross atrophy of the olfactory bulb, which may lead to olfac...

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Autores principales:	Yuko Mishima, Takako Osaki, Atsuyoshi Shimada, Shigeru Kamiya, Sanae Hasegawa-Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/782583b7c1144d43b613712060a30748
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spelling	oai:doaj.org-article:782583b7c1144d43b613712060a307482021-12-02T13:20:02ZSex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice10.1038/s41598-021-83896-52045-2322https://doaj.org/article/782583b7c1144d43b613712060a307482021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83896-5https://doaj.org/toc/2045-2322Abstract A growing body of evidence suggests a relationship between olfactory dysfunction and the pathogenesis of mental disorders. Our previous studies indicated that chronic nasal inflammation caused loss of olfactory sensory neurons and gross atrophy of the olfactory bulb, which may lead to olfactory dysfunction. Simultaneously, increasing numbers of reports have elucidated the importance of gut microbiota to maintain brain function and that dysbiosis may be associated with neuropsychiatric disorders. Here we examined whether chronic nasal inflammation perturbed gut microbiota and whether there were sex differences in this pattern. Eight-week-old C57BL/6 mice repeatedly received bilateral nasal administration of lipopolysaccharide (LPS) 3 times/week to cause chronic nasal inflammation or saline as a control. At 9 weeks, cecal feces were used for 16S metagenomic analysis and whole blood and fresh tissue of spleen were used for ELISA analyses. Microbiome analysis demonstrated a remarkable change of the gut microbiota in male mice with chronic nasal inflammation which was different from that in female mice. In both mice, systemic inflammation did not occur. This has shown for the first time that chronic nasal inflammation correlates with sex-dependent changes in the gut microbiota. The detailed mechanism and potential alteration to brain functions await further studies.Yuko MishimaTakako OsakiAtsuyoshi ShimadaShigeru KamiyaSanae Hasegawa-IshiiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Mishima Takako Osaki Atsuyoshi Shimada Shigeru Kamiya Sanae Hasegawa-Ishii Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
description	Abstract A growing body of evidence suggests a relationship between olfactory dysfunction and the pathogenesis of mental disorders. Our previous studies indicated that chronic nasal inflammation caused loss of olfactory sensory neurons and gross atrophy of the olfactory bulb, which may lead to olfactory dysfunction. Simultaneously, increasing numbers of reports have elucidated the importance of gut microbiota to maintain brain function and that dysbiosis may be associated with neuropsychiatric disorders. Here we examined whether chronic nasal inflammation perturbed gut microbiota and whether there were sex differences in this pattern. Eight-week-old C57BL/6 mice repeatedly received bilateral nasal administration of lipopolysaccharide (LPS) 3 times/week to cause chronic nasal inflammation or saline as a control. At 9 weeks, cecal feces were used for 16S metagenomic analysis and whole blood and fresh tissue of spleen were used for ELISA analyses. Microbiome analysis demonstrated a remarkable change of the gut microbiota in male mice with chronic nasal inflammation which was different from that in female mice. In both mice, systemic inflammation did not occur. This has shown for the first time that chronic nasal inflammation correlates with sex-dependent changes in the gut microbiota. The detailed mechanism and potential alteration to brain functions await further studies.
format	article
author	Yuko Mishima Takako Osaki Atsuyoshi Shimada Shigeru Kamiya Sanae Hasegawa-Ishii
author_facet	Yuko Mishima Takako Osaki Atsuyoshi Shimada Shigeru Kamiya Sanae Hasegawa-Ishii
author_sort	Yuko Mishima
title	Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
title_short	Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
title_full	Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
title_fullStr	Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
title_full_unstemmed	Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
title_sort	sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/782583b7c1144d43b613712060a30748
work_keys_str_mv	AT yukomishima sexdependentdifferencesinthegutmicrobiotafollowingchronicnasalinflammationinadultmice AT takakoosaki sexdependentdifferencesinthegutmicrobiotafollowingchronicnasalinflammationinadultmice AT atsuyoshishimada sexdependentdifferencesinthegutmicrobiotafollowingchronicnasalinflammationinadultmice AT shigerukamiya sexdependentdifferencesinthegutmicrobiotafollowingchronicnasalinflammationinadultmice AT sanaehasegawaishii sexdependentdifferencesinthegutmicrobiotafollowingchronicnasalinflammationinadultmice
_version_	1718393219264282624

Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice

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