A network-centric approach to drugging TNF-induced NF-κB signaling

Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-class small molecules that specifically inhibit TNF-i...

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Autores principales:	Nicolas A. Pabon, Qiuhong Zhang, J. Agustin Cruz, David L. Schipper, Carlos J. Camacho, Robin E. C. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7827aa4fe11a43db972da048c22b3cbb
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spelling	oai:doaj.org-article:7827aa4fe11a43db972da048c22b3cbb2021-12-02T16:58:25ZA network-centric approach to drugging TNF-induced NF-κB signaling10.1038/s41467-019-08802-02041-1723https://doaj.org/article/7827aa4fe11a43db972da048c22b3cbb2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08802-0https://doaj.org/toc/2041-1723Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-class small molecules that specifically inhibit TNF-induced NF-κB activation.Nicolas A. PabonQiuhong ZhangJ. Agustin CruzDavid L. SchipperCarlos J. CamachoRobin E. C. LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas A. Pabon Qiuhong Zhang J. Agustin Cruz David L. Schipper Carlos J. Camacho Robin E. C. Lee A network-centric approach to drugging TNF-induced NF-κB signaling
description	Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-class small molecules that specifically inhibit TNF-induced NF-κB activation.
format	article
author	Nicolas A. Pabon Qiuhong Zhang J. Agustin Cruz David L. Schipper Carlos J. Camacho Robin E. C. Lee
author_facet	Nicolas A. Pabon Qiuhong Zhang J. Agustin Cruz David L. Schipper Carlos J. Camacho Robin E. C. Lee
author_sort	Nicolas A. Pabon
title	A network-centric approach to drugging TNF-induced NF-κB signaling
title_short	A network-centric approach to drugging TNF-induced NF-κB signaling
title_full	A network-centric approach to drugging TNF-induced NF-κB signaling
title_fullStr	A network-centric approach to drugging TNF-induced NF-κB signaling
title_full_unstemmed	A network-centric approach to drugging TNF-induced NF-κB signaling
title_sort	network-centric approach to drugging tnf-induced nf-κb signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7827aa4fe11a43db972da048c22b3cbb
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A network-centric approach to drugging TNF-induced NF-κB signaling

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