Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro

Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells...

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Autores principales: Xiaoyu Zhang, Sumedha Gunewardena, Ning Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e7
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spelling oai:doaj.org-article:7827bdb210bb4ff2a98710f8712847e72021-12-02T11:39:32ZNutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro10.1038/s41467-021-22021-62041-1723https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22021-6https://doaj.org/toc/2041-1723Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells.Xiaoyu ZhangSumedha GunewardenaNing WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaoyu Zhang
Sumedha Gunewardena
Ning Wang
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
description Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells.
format article
author Xiaoyu Zhang
Sumedha Gunewardena
Ning Wang
author_facet Xiaoyu Zhang
Sumedha Gunewardena
Ning Wang
author_sort Xiaoyu Zhang
title Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_short Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_full Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_fullStr Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_full_unstemmed Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_sort nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e7
work_keys_str_mv AT xiaoyuzhang nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro
AT sumedhagunewardena nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro
AT ningwang nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro
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