Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells...
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Nature Portfolio
2021
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oai:doaj.org-article:7827bdb210bb4ff2a98710f8712847e72021-12-02T11:39:32ZNutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro10.1038/s41467-021-22021-62041-1723https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22021-6https://doaj.org/toc/2041-1723Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells.Xiaoyu ZhangSumedha GunewardenaNing WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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Science Q Xiaoyu Zhang Sumedha Gunewardena Ning Wang Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
description |
Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells. |
format |
article |
author |
Xiaoyu Zhang Sumedha Gunewardena Ning Wang |
author_facet |
Xiaoyu Zhang Sumedha Gunewardena Ning Wang |
author_sort |
Xiaoyu Zhang |
title |
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
title_short |
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
title_full |
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
title_fullStr |
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
title_full_unstemmed |
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
title_sort |
nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e7 |
work_keys_str_mv |
AT xiaoyuzhang nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro AT sumedhagunewardena nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro AT ningwang nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro |
_version_ |
1718395707475361792 |