Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro

Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells...

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Main Authors:	Xiaoyu Zhang, Sumedha Gunewardena, Ning Wang
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e7
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spelling	oai:doaj.org-article:7827bdb210bb4ff2a98710f8712847e72021-12-02T11:39:32ZNutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro10.1038/s41467-021-22021-62041-1723https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22021-6https://doaj.org/toc/2041-1723Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells.Xiaoyu ZhangSumedha GunewardenaNing WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyu Zhang Sumedha Gunewardena Ning Wang Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
description	Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene and chromosome programs in mammalian germ cells.
format	article
author	Xiaoyu Zhang Sumedha Gunewardena Ning Wang
author_facet	Xiaoyu Zhang Sumedha Gunewardena Ning Wang
author_sort	Xiaoyu Zhang
title	Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_short	Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_full	Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_fullStr	Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_full_unstemmed	Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
title_sort	nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7827bdb210bb4ff2a98710f8712847e7
work_keys_str_mv	AT xiaoyuzhang nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro AT sumedhagunewardena nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro AT ningwang nutrientrestrictionsynergizeswithretinoicacidtoinducemammalianmeioticinitiationinvitro
_version_	1718395707475361792

Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro

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