Structure of the processive human Pol δ holoenzyme

Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structure of the human 4-subunit Pol δ bound to DNA and PCN...

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Autores principales:	Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan, Alfredo De Biasio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/782ada8b374241e2b47934138793c3f7
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spelling	oai:doaj.org-article:782ada8b374241e2b47934138793c3f72021-12-02T15:37:12ZStructure of the processive human Pol δ holoenzyme10.1038/s41467-020-14898-62041-1723https://doaj.org/article/782ada8b374241e2b47934138793c3f72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14898-6https://doaj.org/toc/2041-1723Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structure of the human 4-subunit Pol δ bound to DNA and PCNA in a replicating state with an incoming nucleotide in the active site.Claudia LanceyMuhammad TehseenVlad-Stefan RaducanuFahad RashidNekane MerinoTimothy J. RaganChristos G. SavvaManal S. ZaherAfnan ShirbiniFrancisco J. BlancoSamir M. HamdanAlfredo De BiasioNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia Lancey Muhammad Tehseen Vlad-Stefan Raducanu Fahad Rashid Nekane Merino Timothy J. Ragan Christos G. Savva Manal S. Zaher Afnan Shirbini Francisco J. Blanco Samir M. Hamdan Alfredo De Biasio Structure of the processive human Pol δ holoenzyme
description	Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structure of the human 4-subunit Pol δ bound to DNA and PCNA in a replicating state with an incoming nucleotide in the active site.
format	article
author	Claudia Lancey Muhammad Tehseen Vlad-Stefan Raducanu Fahad Rashid Nekane Merino Timothy J. Ragan Christos G. Savva Manal S. Zaher Afnan Shirbini Francisco J. Blanco Samir M. Hamdan Alfredo De Biasio
author_facet	Claudia Lancey Muhammad Tehseen Vlad-Stefan Raducanu Fahad Rashid Nekane Merino Timothy J. Ragan Christos G. Savva Manal S. Zaher Afnan Shirbini Francisco J. Blanco Samir M. Hamdan Alfredo De Biasio
author_sort	Claudia Lancey
title	Structure of the processive human Pol δ holoenzyme
title_short	Structure of the processive human Pol δ holoenzyme
title_full	Structure of the processive human Pol δ holoenzyme
title_fullStr	Structure of the processive human Pol δ holoenzyme
title_full_unstemmed	Structure of the processive human Pol δ holoenzyme
title_sort	structure of the processive human pol δ holoenzyme
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/782ada8b374241e2b47934138793c3f7
work_keys_str_mv	AT claudialancey structureoftheprocessivehumanpoldholoenzyme AT muhammadtehseen structureoftheprocessivehumanpoldholoenzyme AT vladstefanraducanu structureoftheprocessivehumanpoldholoenzyme AT fahadrashid structureoftheprocessivehumanpoldholoenzyme AT nekanemerino structureoftheprocessivehumanpoldholoenzyme AT timothyjragan structureoftheprocessivehumanpoldholoenzyme AT christosgsavva structureoftheprocessivehumanpoldholoenzyme AT manalszaher structureoftheprocessivehumanpoldholoenzyme AT afnanshirbini structureoftheprocessivehumanpoldholoenzyme AT franciscojblanco structureoftheprocessivehumanpoldholoenzyme AT samirmhamdan structureoftheprocessivehumanpoldholoenzyme AT alfredodebiasio structureoftheprocessivehumanpoldholoenzyme
_version_	1718386240939622400

Structure of the processive human Pol δ holoenzyme

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