Altered functional connectivity of primary visual cortex in late blindness

Zhi Wen,1,* Fu-Qing Zhou,2,* Xin Huang,3 Han Dong Dan,3 Bao-Jun Xie,1 Yin Shen3 1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Insti...

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Autores principales:	Wen Z, Zhou FQ, Huang X, Dan HD, Xie BJ, Shen Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	late blindness functional connectivity primary visual area functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/782b2059f4924fea8af3bcea94436571
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spelling	oai:doaj.org-article:782b2059f4924fea8af3bcea944365712021-12-02T02:45:31ZAltered functional connectivity of primary visual cortex in late blindness1178-2021https://doaj.org/article/782b2059f4924fea8af3bcea944365712018-12-01T00:00:00Zhttps://www.dovepress.com/altered-functional-connectivity-of-primary-visual-cortex-in-late-blind-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhi Wen,1,* Fu-Qing Zhou,2,* Xin Huang,3 Han Dong Dan,3 Bao-Jun Xie,1 Yin Shen3 1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, 330006, Jiangxi, China; 3Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China *These authors contributed equally to this work Background: Previous studies demonstrated that early blindness is associated with abnormal intrinsic functional connectivity (FC) between the primary visual cortex (V1) and other sensory areas. However, the V1 pattern of spontaneous neural activity occurring in late blindness (LB) remains unknown. The purpose of this study was to investigate the intrinsic FC patterns of V1 in LB. Materials and methods: Thirty LB individuals (18 males and 12 females; mean age: 38.76±14.43 years) and 30 sighted controls (SCs) individuals (18 males and 12 females; mean age: 38.67±13.85 years) closely matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. Region of interest analysis was performed to extract the correlation coefficient matrix among each pair of Brodmann area (BA) 17 and FC between V1 and vision-related subcortical nuclei.Results: Compared with SCs, LB individuals showed a decreased FC between the left V1 and the bilateral cuneus (CUN)/lingual gyrus (LGG)/calcarine (CAL) (BA 18/19/30) and left precentral gyrus (PreCG) and the postcentral gyrus (PostCG) (BA 2/3/4). Also, LB individuals showed a decreased FC between the right V1 and the bilateral CUN/LGG/CAL (BA 18/19/30) and the left PreCG and PostCG (BA 2/3/4/6) (voxel-level: P<0.01, cluster-level: P<0.05). Meanwhile, LB individuals showed a decreased FC between the left V1 and the right V1 and increased FC between the left V1 and the right superior colliculus, the right V1, and the left hippocampus (P<0.05). Moreover, a positive correlation was observed between the onset age of blindness and FC values in V1 to CUN/LGG/CAL in LB.Conclusion: Our results highlighted that LB induces a decreased FC between V1 and higher visual areas, motor cortices, and somatosensory cortices at rest. This might indicate that LB humans could present with impaired top-down modulations, visual imagery, and vision-motor function.Keywords: late blindness, intrinsic functional connectivity, primary visual area, functional magnetic resonance imaging Wen ZZhou FQHuang XDan HDXie BJShen YDove Medical Pressarticlelate blindnessfunctional connectivityprimary visual areafunctional magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3317-3327 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	late blindness functional connectivity primary visual area functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	late blindness functional connectivity primary visual area functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wen Z Zhou FQ Huang X Dan HD Xie BJ Shen Y Altered functional connectivity of primary visual cortex in late blindness
description	Zhi Wen,1,* Fu-Qing Zhou,2,* Xin Huang,3 Han Dong Dan,3 Bao-Jun Xie,1 Yin Shen3 1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, 330006, Jiangxi, China; 3Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China *These authors contributed equally to this work Background: Previous studies demonstrated that early blindness is associated with abnormal intrinsic functional connectivity (FC) between the primary visual cortex (V1) and other sensory areas. However, the V1 pattern of spontaneous neural activity occurring in late blindness (LB) remains unknown. The purpose of this study was to investigate the intrinsic FC patterns of V1 in LB. Materials and methods: Thirty LB individuals (18 males and 12 females; mean age: 38.76±14.43 years) and 30 sighted controls (SCs) individuals (18 males and 12 females; mean age: 38.67±13.85 years) closely matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. Region of interest analysis was performed to extract the correlation coefficient matrix among each pair of Brodmann area (BA) 17 and FC between V1 and vision-related subcortical nuclei.Results: Compared with SCs, LB individuals showed a decreased FC between the left V1 and the bilateral cuneus (CUN)/lingual gyrus (LGG)/calcarine (CAL) (BA 18/19/30) and left precentral gyrus (PreCG) and the postcentral gyrus (PostCG) (BA 2/3/4). Also, LB individuals showed a decreased FC between the right V1 and the bilateral CUN/LGG/CAL (BA 18/19/30) and the left PreCG and PostCG (BA 2/3/4/6) (voxel-level: P<0.01, cluster-level: P<0.05). Meanwhile, LB individuals showed a decreased FC between the left V1 and the right V1 and increased FC between the left V1 and the right superior colliculus, the right V1, and the left hippocampus (P<0.05). Moreover, a positive correlation was observed between the onset age of blindness and FC values in V1 to CUN/LGG/CAL in LB.Conclusion: Our results highlighted that LB induces a decreased FC between V1 and higher visual areas, motor cortices, and somatosensory cortices at rest. This might indicate that LB humans could present with impaired top-down modulations, visual imagery, and vision-motor function.Keywords: late blindness, intrinsic functional connectivity, primary visual area, functional magnetic resonance imaging
format	article
author	Wen Z Zhou FQ Huang X Dan HD Xie BJ Shen Y
author_facet	Wen Z Zhou FQ Huang X Dan HD Xie BJ Shen Y
author_sort	Wen Z
title	Altered functional connectivity of primary visual cortex in late blindness
title_short	Altered functional connectivity of primary visual cortex in late blindness
title_full	Altered functional connectivity of primary visual cortex in late blindness
title_fullStr	Altered functional connectivity of primary visual cortex in late blindness
title_full_unstemmed	Altered functional connectivity of primary visual cortex in late blindness
title_sort	altered functional connectivity of primary visual cortex in late blindness
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/782b2059f4924fea8af3bcea94436571
work_keys_str_mv	AT wenz alteredfunctionalconnectivityofprimaryvisualcortexinlateblindness AT zhoufq alteredfunctionalconnectivityofprimaryvisualcortexinlateblindness AT huangx alteredfunctionalconnectivityofprimaryvisualcortexinlateblindness AT danhd alteredfunctionalconnectivityofprimaryvisualcortexinlateblindness AT xiebj alteredfunctionalconnectivityofprimaryvisualcortexinlateblindness AT sheny alteredfunctionalconnectivityofprimaryvisualcortexinlateblindness
_version_	1718402169167675392

Altered functional connectivity of primary visual cortex in late blindness

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