Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.

<h4>Objective</h4>Physical activity has been shown to attenuate the effect of the FTO polymorphism on body weight, and the heritability of body weight in twin and in family studies. The dose-response relationship between activity and the risk for inherited obesity is not well known, part...

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Autor principal:	Paul T Williams
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/782c2403208a49f4b73b82fb0956fa6c
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spelling	oai:doaj.org-article:782c2403208a49f4b73b82fb0956fa6c2021-11-18T07:26:57ZAttenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.1932-620310.1371/journal.pone.0031436https://doaj.org/article/782c2403208a49f4b73b82fb0956fa6c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384023/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Physical activity has been shown to attenuate the effect of the FTO polymorphism on body weight, and the heritability of body weight in twin and in family studies. The dose-response relationship between activity and the risk for inherited obesity is not well known, particularly for higher doses of vigorous exercise. Such information is needed to best prescribe an exercise dose for obesity prevention in those at risk due to their family history.<h4>Design</h4>We therefore analyzed self-reported usual running distance, body mass index (BMI), waist circumference, and mother's and father's adiposity (1 = lean, 2 = normal, 3 = overweight, and 4 = very overweight) from survey data collected on 33,480 male and 14,211 female runners. Age-, education-, and alcohol-adjusted regression analyses were used to estimate the contribution of parental adiposities to the BMI and waist circumferences in runners who ran an average of <3, 3-6, 6-9, ≥ 9 km/day.<h4>Results</h4>BMI and waist circumferences of runners who ran <3 km/day were significantly related to their parents adiposity (P<10(-15) and P<10(-11), respectively). These relationships (i.e., kg/m(2) or cm per increment in parental adiposity) diminished significantly with increasing running distance for both BMI (inheritance×exercise interaction, males: P<10(-10); females: P<10(-5)) and waist circumference (inheritance × exercise interaction, males: P<10(-9); females: P = 0.004). Compared to <3 km/day, the parental contribution to runners who averaged ≥ 9 km/day was diminished by 48% for male BMI, 58% for female BMI, 55% for male waist circumference, and 58% for female waist circumference. These results could not be attributed to self-selection.<h4>Conclusions</h4>Exceeding the minimum exercise dose currently recommended for general health benefits (energy equivalent to running 2-3 km/day) may substantially diminish the risk for inherited obesity. The results are consistent with other research suggesting the physical activity dose required to prevent unhealthy weight gain is greater than that recommended for other health benefits.Paul T WilliamsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31436 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul T Williams Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
description	<h4>Objective</h4>Physical activity has been shown to attenuate the effect of the FTO polymorphism on body weight, and the heritability of body weight in twin and in family studies. The dose-response relationship between activity and the risk for inherited obesity is not well known, particularly for higher doses of vigorous exercise. Such information is needed to best prescribe an exercise dose for obesity prevention in those at risk due to their family history.<h4>Design</h4>We therefore analyzed self-reported usual running distance, body mass index (BMI), waist circumference, and mother's and father's adiposity (1 = lean, 2 = normal, 3 = overweight, and 4 = very overweight) from survey data collected on 33,480 male and 14,211 female runners. Age-, education-, and alcohol-adjusted regression analyses were used to estimate the contribution of parental adiposities to the BMI and waist circumferences in runners who ran an average of <3, 3-6, 6-9, ≥ 9 km/day.<h4>Results</h4>BMI and waist circumferences of runners who ran <3 km/day were significantly related to their parents adiposity (P<10(-15) and P<10(-11), respectively). These relationships (i.e., kg/m(2) or cm per increment in parental adiposity) diminished significantly with increasing running distance for both BMI (inheritance×exercise interaction, males: P<10(-10); females: P<10(-5)) and waist circumference (inheritance × exercise interaction, males: P<10(-9); females: P = 0.004). Compared to <3 km/day, the parental contribution to runners who averaged ≥ 9 km/day was diminished by 48% for male BMI, 58% for female BMI, 55% for male waist circumference, and 58% for female waist circumference. These results could not be attributed to self-selection.<h4>Conclusions</h4>Exceeding the minimum exercise dose currently recommended for general health benefits (energy equivalent to running 2-3 km/day) may substantially diminish the risk for inherited obesity. The results are consistent with other research suggesting the physical activity dose required to prevent unhealthy weight gain is greater than that recommended for other health benefits.
format	article
author	Paul T Williams
author_facet	Paul T Williams
author_sort	Paul T Williams
title	Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
title_short	Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
title_full	Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
title_fullStr	Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
title_full_unstemmed	Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
title_sort	attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/782c2403208a49f4b73b82fb0956fa6c
work_keys_str_mv	AT paultwilliams attenuatingeffectofvigorousphysicalactivityontheriskforinheritedobesityastudyof47691runners
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Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.

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