Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials
Objective: To evaluate the maintenance effect of probiotics versus that of aminosalicylates on ulcerative colitis. Methods: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the Chinese Biomedical Database were searched in English or Chinese. Data extracted were selected with strict crit...
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KeAi Communications Co., Ltd.
2016
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oai:doaj.org-article:782d1cf3c83549e38e040674d800c96e2021-12-02T14:21:36ZComparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials2095-882X10.1016/j.cdtm.2016.07.002https://doaj.org/article/782d1cf3c83549e38e040674d800c96e2016-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300202https://doaj.org/toc/2095-882XObjective: To evaluate the maintenance effect of probiotics versus that of aminosalicylates on ulcerative colitis. Methods: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the Chinese Biomedical Database were searched in English or Chinese. Data extracted were selected with strict criteria. Results: In six randomized controlled trials (RCTs), a total of 721 participants were enrolled and the maintenance effect of probiotics (n = 364) versus that of aminosalicylates (n = 357) on ulcerative colitis was investigated. No significant difference was observed between probiotics and aminosalicylate groups (relative risk (RR) = 1.08; 95% confidence interval (CI): 0.91â1.28; P = 0.40). Three RCTs compared the incidence of adverse events with probiotics versus those with aminosalicylates. No significant difference was observed in the incidence of adverse events between the two groups (RR = 1.20; 95% CI: 0.92â1.56; P = 0.17). Conclusions: Probiotics and aminosalicylates both showed a maintenance effect on ulcerative colitis. However, more well-designed RCTs are required. Keywords: Maintenance effect, Probiotics, Aminosalicylates, Ulcerative colitis, Meta-analysisYong JiangZhi-Guang ZhangFeng-Xiang QiYing ZhangTao HanKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 1, Pp 34-41 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine (General) R5-920 |
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Medicine (General) R5-920 Yong Jiang Zhi-Guang Zhang Feng-Xiang Qi Ying Zhang Tao Han Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials |
| description |
Objective: To evaluate the maintenance effect of probiotics versus that of aminosalicylates on ulcerative colitis. Methods: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the Chinese Biomedical Database were searched in English or Chinese. Data extracted were selected with strict criteria. Results: In six randomized controlled trials (RCTs), a total of 721 participants were enrolled and the maintenance effect of probiotics (n = 364) versus that of aminosalicylates (n = 357) on ulcerative colitis was investigated. No significant difference was observed between probiotics and aminosalicylate groups (relative risk (RR) = 1.08; 95% confidence interval (CI): 0.91â1.28; P = 0.40). Three RCTs compared the incidence of adverse events with probiotics versus those with aminosalicylates. No significant difference was observed in the incidence of adverse events between the two groups (RR = 1.20; 95% CI: 0.92â1.56; P = 0.17). Conclusions: Probiotics and aminosalicylates both showed a maintenance effect on ulcerative colitis. However, more well-designed RCTs are required. Keywords: Maintenance effect, Probiotics, Aminosalicylates, Ulcerative colitis, Meta-analysis |
| format |
article |
| author |
Yong Jiang Zhi-Guang Zhang Feng-Xiang Qi Ying Zhang Tao Han |
| author_facet |
Yong Jiang Zhi-Guang Zhang Feng-Xiang Qi Ying Zhang Tao Han |
| author_sort |
Yong Jiang |
| title |
Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials |
| title_short |
Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials |
| title_full |
Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials |
| title_fullStr |
Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials |
| title_full_unstemmed |
Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials |
| title_sort |
comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: a meta-analysis of randomized controlled trials |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2016 |
| url |
https://doaj.org/article/782d1cf3c83549e38e040674d800c96e |
| work_keys_str_mv |
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