Determinants of transcription factor regulatory range

Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of regulatory influence modulated by chromatin sta...

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Autores principales:	Chen-Hao Chen, Rongbin Zheng, Collin Tokheim, Xin Dong, Jingyu Fan, Changxin Wan, Qin Tang, Myles Brown, Jun S. Liu, Clifford A. Meyer, X. Shirley Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78325609a2444fecaf9d8aaf4a86bf49
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spelling	oai:doaj.org-article:78325609a2444fecaf9d8aaf4a86bf492021-12-02T15:45:30ZDeterminants of transcription factor regulatory range10.1038/s41467-020-16106-x2041-1723https://doaj.org/article/78325609a2444fecaf9d8aaf4a86bf492020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16106-xhttps://doaj.org/toc/2041-1723Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of regulatory influence modulated by chromatin states of topologically associated domains.Chen-Hao ChenRongbin ZhengCollin TokheimXin DongJingyu FanChangxin WanQin TangMyles BrownJun S. LiuClifford A. MeyerX. Shirley LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen-Hao Chen Rongbin Zheng Collin Tokheim Xin Dong Jingyu Fan Changxin Wan Qin Tang Myles Brown Jun S. Liu Clifford A. Meyer X. Shirley Liu Determinants of transcription factor regulatory range
description	Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of regulatory influence modulated by chromatin states of topologically associated domains.
format	article
author	Chen-Hao Chen Rongbin Zheng Collin Tokheim Xin Dong Jingyu Fan Changxin Wan Qin Tang Myles Brown Jun S. Liu Clifford A. Meyer X. Shirley Liu
author_facet	Chen-Hao Chen Rongbin Zheng Collin Tokheim Xin Dong Jingyu Fan Changxin Wan Qin Tang Myles Brown Jun S. Liu Clifford A. Meyer X. Shirley Liu
author_sort	Chen-Hao Chen
title	Determinants of transcription factor regulatory range
title_short	Determinants of transcription factor regulatory range
title_full	Determinants of transcription factor regulatory range
title_fullStr	Determinants of transcription factor regulatory range
title_full_unstemmed	Determinants of transcription factor regulatory range
title_sort	determinants of transcription factor regulatory range
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/78325609a2444fecaf9d8aaf4a86bf49
work_keys_str_mv	AT chenhaochen determinantsoftranscriptionfactorregulatoryrange AT rongbinzheng determinantsoftranscriptionfactorregulatoryrange AT collintokheim determinantsoftranscriptionfactorregulatoryrange AT xindong determinantsoftranscriptionfactorregulatoryrange AT jingyufan determinantsoftranscriptionfactorregulatoryrange AT changxinwan determinantsoftranscriptionfactorregulatoryrange AT qintang determinantsoftranscriptionfactorregulatoryrange AT mylesbrown determinantsoftranscriptionfactorregulatoryrange AT junsliu determinantsoftranscriptionfactorregulatoryrange AT cliffordameyer determinantsoftranscriptionfactorregulatoryrange AT xshirleyliu determinantsoftranscriptionfactorregulatoryrange
_version_	1718385758485610496

Determinants of transcription factor regulatory range

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