DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effec...

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Autores principales:	Rajbir Nath Batra, Aviezer Lifshitz, Ana Tufegdzic Vidakovic, Suet-Feung Chin, Ankita Sati-Batra, Stephen-John Sammut, Elena Provenzano, H. Raza Ali, Ali Dariush, Alejandra Bruna, Leigh Murphy, Arnie Purushotham, Ian Ellis, Andrew Green, Francine E. Garrett-Bakelman, Chris Mason, Ari Melnick, Samuel A. J. R. Aparicio, Oscar M. Rueda, Amos Tanay, Carlos Caldas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7832b4cd7ff242839e4e5e73265c879e
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spelling	oai:doaj.org-article:7832b4cd7ff242839e4e5e73265c879e2021-12-02T18:50:53ZDNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation10.1038/s41467-021-25661-w2041-1723https://doaj.org/article/7832b4cd7ff242839e4e5e73265c879e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25661-whttps://doaj.org/toc/2041-1723Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effects.Rajbir Nath BatraAviezer LifshitzAna Tufegdzic VidakovicSuet-Feung ChinAnkita Sati-BatraStephen-John SammutElena ProvenzanoH. Raza AliAli DariushAlejandra BrunaLeigh MurphyArnie PurushothamIan EllisAndrew GreenFrancine E. Garrett-BakelmanChris MasonAri MelnickSamuel A. J. R. AparicioOscar M. RuedaAmos TanayCarlos CaldasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajbir Nath Batra Aviezer Lifshitz Ana Tufegdzic Vidakovic Suet-Feung Chin Ankita Sati-Batra Stephen-John Sammut Elena Provenzano H. Raza Ali Ali Dariush Alejandra Bruna Leigh Murphy Arnie Purushotham Ian Ellis Andrew Green Francine E. Garrett-Bakelman Chris Mason Ari Melnick Samuel A. J. R. Aparicio Oscar M. Rueda Amos Tanay Carlos Caldas DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
description	Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effects.
format	article
author	Rajbir Nath Batra Aviezer Lifshitz Ana Tufegdzic Vidakovic Suet-Feung Chin Ankita Sati-Batra Stephen-John Sammut Elena Provenzano H. Raza Ali Ali Dariush Alejandra Bruna Leigh Murphy Arnie Purushotham Ian Ellis Andrew Green Francine E. Garrett-Bakelman Chris Mason Ari Melnick Samuel A. J. R. Aparicio Oscar M. Rueda Amos Tanay Carlos Caldas
author_facet	Rajbir Nath Batra Aviezer Lifshitz Ana Tufegdzic Vidakovic Suet-Feung Chin Ankita Sati-Batra Stephen-John Sammut Elena Provenzano H. Raza Ali Ali Dariush Alejandra Bruna Leigh Murphy Arnie Purushotham Ian Ellis Andrew Green Francine E. Garrett-Bakelman Chris Mason Ari Melnick Samuel A. J. R. Aparicio Oscar M. Rueda Amos Tanay Carlos Caldas
author_sort	Rajbir Nath Batra
title	DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
title_short	DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
title_full	DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
title_fullStr	DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
title_full_unstemmed	DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
title_sort	dna methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7832b4cd7ff242839e4e5e73265c879e
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DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

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