Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice

Abstract The widely-used herbicide atrazine (ATZ) is detected in ground and surface water in many countries. Several studies in animals have demonstrated that ATZ has endocrine-disrupting effects on male and female reproduction in many vertebrate species. In this study, we investigated the effects o...

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Autores principales:	Aurore Gely-Pernot, Souhila Saci, Pierre-Yves Kernanec, Chunxiang Hao, Frank Giton, Christine Kervarrec, Sergei Tevosian, Severine Mazaud-Guittot, Fatima Smagulova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7832ed990fe6482290b0777c97709927
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spelling	oai:doaj.org-article:7832ed990fe6482290b0777c977099272021-12-02T11:40:43ZEmbryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice10.1038/s41598-017-03738-12045-2322https://doaj.org/article/7832ed990fe6482290b0777c977099272017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03738-1https://doaj.org/toc/2045-2322Abstract The widely-used herbicide atrazine (ATZ) is detected in ground and surface water in many countries. Several studies in animals have demonstrated that ATZ has endocrine-disrupting effects on male and female reproduction in many vertebrate species. In this study, we investigated the effects of ATZ exposure on meiosis, a key step in gametogenesis in mammals. The treatment was initiated before oocyte entry into meiosis, which occurs during the embryonic period in females. We found that embryonic exposure to ATZ increases the level of 8-oxo-guanine in the nucleus of meiotic cells, reflecting oxidative stress and affecting meiotic double-strand break repair, chromosome synapsis and crossover numbers. Finally, embryonic exposure to ATZ reduces the number of primordial follicles and increases the incidence of multi-oocyte follicles in adult mice. Our data demonstrate that embryonic exposure to ATZ disrupts prophase I of meiosis and affects normal follicle formation in female mice.Aurore Gely-PernotSouhila SaciPierre-Yves KernanecChunxiang HaoFrank GitonChristine KervarrecSergei TevosianSeverine Mazaud-GuittotFatima SmagulovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aurore Gely-Pernot Souhila Saci Pierre-Yves Kernanec Chunxiang Hao Frank Giton Christine Kervarrec Sergei Tevosian Severine Mazaud-Guittot Fatima Smagulova Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
description	Abstract The widely-used herbicide atrazine (ATZ) is detected in ground and surface water in many countries. Several studies in animals have demonstrated that ATZ has endocrine-disrupting effects on male and female reproduction in many vertebrate species. In this study, we investigated the effects of ATZ exposure on meiosis, a key step in gametogenesis in mammals. The treatment was initiated before oocyte entry into meiosis, which occurs during the embryonic period in females. We found that embryonic exposure to ATZ increases the level of 8-oxo-guanine in the nucleus of meiotic cells, reflecting oxidative stress and affecting meiotic double-strand break repair, chromosome synapsis and crossover numbers. Finally, embryonic exposure to ATZ reduces the number of primordial follicles and increases the incidence of multi-oocyte follicles in adult mice. Our data demonstrate that embryonic exposure to ATZ disrupts prophase I of meiosis and affects normal follicle formation in female mice.
format	article
author	Aurore Gely-Pernot Souhila Saci Pierre-Yves Kernanec Chunxiang Hao Frank Giton Christine Kervarrec Sergei Tevosian Severine Mazaud-Guittot Fatima Smagulova
author_facet	Aurore Gely-Pernot Souhila Saci Pierre-Yves Kernanec Chunxiang Hao Frank Giton Christine Kervarrec Sergei Tevosian Severine Mazaud-Guittot Fatima Smagulova
author_sort	Aurore Gely-Pernot
title	Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
title_short	Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
title_full	Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
title_fullStr	Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
title_full_unstemmed	Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
title_sort	embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7832ed990fe6482290b0777c97709927
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Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice

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