miR-346 controls release of TNF-α protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization.

miR-346 controls release of TNF-α protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization.

TNF-α is a major cytokine implicated in rheumatoid arthritis. Its expression is regulated both at the transcriptional and posttranscriptional levels and recent data demonstrated that miRNAs are implicated in TNF-α response in macrophages. LPS-activated FLS isolated from RA patients express TNF-α mRN...

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Autores principales: Noha Semaan, Laurent Frenzel, Ghada Alsaleh, Guillaume Suffert, Jacques-Eric Gottenberg, Jean Sibilia, Sebastien Pfeffer, Dominique Wachsmann
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/783400689f68411591c8db424fa80bd8
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