Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor.

The RNA guanylyltransferase (GTase) is involved in the synthesis of the (m7)Gppp-RNA cap structure found at the 5' end of eukaryotic mRNAs. GTases are members of the covalent nucleotidyl transferase superfamily, which also includes DNA and RNA ligases. GTases catalyze a two-step reaction in whi...

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Autores principales: Maude Tremblay-Létourneau, Simon Despins, Isabelle Bougie, Martin Bisaillon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/7835f4b3119543c9be163e02345e506a
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