Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn

INTRODUCTION: The UVB exposure may cause sunburn (second degree burn). Aloe vera (AV) is widely used in wound healing, including sunburn. OBJECTIVE: To evaluate the effect of topical Aloe vera extract gel on the number of macrophages and epithelialization in UVB induced sunburn. METHODS: This pos...

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Autores principales: Ersje Retnowati Tadihoedojo, Edi Dharmana, Chodidjah Chodidjah
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Publicado: Universitas Sultan Agung Semarang 2019
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Acceso en línea:https://doaj.org/article/7836f73fecee46519c09951a481d6f71
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spelling oai:doaj.org-article:7836f73fecee46519c09951a481d6f712021-11-25T13:16:18ZTopical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn2085-15452339-093Xhttps://doaj.org/article/7836f73fecee46519c09951a481d6f712019-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/2518https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XINTRODUCTION: The UVB exposure may cause sunburn (second degree burn). Aloe vera (AV) is widely used in wound healing, including sunburn. OBJECTIVE: To evaluate the effect of topical Aloe vera extract gel on the number of macrophages and epithelialization in UVB induced sunburn. METHODS: This posttest only-control group design used twenty female BALB/c mice with UVB-induced sunburn randomly divided into 4 groups. Control groups (Cntrl-G) were given a base gel. Group AV-25, AV-50, and AV-75 were topically treated with Aloe vera gel at the concentration of 25%, 50% and 75% respectively for 5 days. On day 5, after terminated, the samples of skin tissue were prepared for histological study using hematoxlyin eosin (HE) staining. Data were analyzed using one way ANOVA, Post-hoc LSD and Pearson correlation. RESULTS: ANOVA analysis showed that the number of macrophages and epithelialization among groups was a significantly difference (p <0.05). Post hoc analysis demonstrated that the mean number of macrophage in AV-75 (6.50), AV-50 (5.13), and AV-25 (3.93) were significantly higher compared to that of Cntrl-G (2.93). The mean of epithelialization AV-75% (25.35), AV-50 (18.15), and AV-25 (15.38), were significantly (p <0.05) higher compared to that of Cntrl-G (9.30). The Pearson correlation test indicated that there is a strong positive correlation (0.88) between the number of macrophages and epithelialization (p <0.05). CONCLUSION: The topical administration of Aloe vera gel extract for five days increased the number of macrophages and epithelialization in sunburned UVB induced sun burn.Ersje Retnowati TadihoedojoEdi DharmanaChodidjah ChodidjahUniversitas Sultan Agung Semarangarticlesunburn, aloe vera, macrophages, epithelializationMedicine (General)R5-920ENSains Medika, Vol 10, Iss 1, Pp 26-31 (2019)
institution DOAJ
collection DOAJ
language EN
topic sunburn, aloe vera, macrophages, epithelialization
Medicine (General)
R5-920
spellingShingle sunburn, aloe vera, macrophages, epithelialization
Medicine (General)
R5-920
Ersje Retnowati Tadihoedojo
Edi Dharmana
Chodidjah Chodidjah
Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn
description INTRODUCTION: The UVB exposure may cause sunburn (second degree burn). Aloe vera (AV) is widely used in wound healing, including sunburn. OBJECTIVE: To evaluate the effect of topical Aloe vera extract gel on the number of macrophages and epithelialization in UVB induced sunburn. METHODS: This posttest only-control group design used twenty female BALB/c mice with UVB-induced sunburn randomly divided into 4 groups. Control groups (Cntrl-G) were given a base gel. Group AV-25, AV-50, and AV-75 were topically treated with Aloe vera gel at the concentration of 25%, 50% and 75% respectively for 5 days. On day 5, after terminated, the samples of skin tissue were prepared for histological study using hematoxlyin eosin (HE) staining. Data were analyzed using one way ANOVA, Post-hoc LSD and Pearson correlation. RESULTS: ANOVA analysis showed that the number of macrophages and epithelialization among groups was a significantly difference (p <0.05). Post hoc analysis demonstrated that the mean number of macrophage in AV-75 (6.50), AV-50 (5.13), and AV-25 (3.93) were significantly higher compared to that of Cntrl-G (2.93). The mean of epithelialization AV-75% (25.35), AV-50 (18.15), and AV-25 (15.38), were significantly (p <0.05) higher compared to that of Cntrl-G (9.30). The Pearson correlation test indicated that there is a strong positive correlation (0.88) between the number of macrophages and epithelialization (p <0.05). CONCLUSION: The topical administration of Aloe vera gel extract for five days increased the number of macrophages and epithelialization in sunburned UVB induced sun burn.
format article
author Ersje Retnowati Tadihoedojo
Edi Dharmana
Chodidjah Chodidjah
author_facet Ersje Retnowati Tadihoedojo
Edi Dharmana
Chodidjah Chodidjah
author_sort Ersje Retnowati Tadihoedojo
title Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn
title_short Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn
title_full Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn
title_fullStr Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn
title_full_unstemmed Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn
title_sort topical administration of aloe vera extract gel increased the number of macrophages and epithelialization in uvb-induced sunburn
publisher Universitas Sultan Agung Semarang
publishDate 2019
url https://doaj.org/article/7836f73fecee46519c09951a481d6f71
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AT edidharmana topicaladministrationofaloeveraextractgelincreasedthenumberofmacrophagesandepithelializationinuvbinducedsunburn
AT chodidjahchodidjah topicaladministrationofaloeveraextractgelincreasedthenumberofmacrophagesandepithelializationinuvbinducedsunburn
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