Benfluorex and unexplained valvular heart disease: a case-control study.

<h4>Background</h4>Recent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation.<h4>Methods</h4>We conducted a case-control study. Eligible patien...

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Autores principales:	Irène Frachon, Yves Etienne, Yannick Jobic, Grégoire Le Gal, Marc Humbert, Christophe Leroyer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/783878fcc1a94d1eb71fc3cc69bea834
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spelling	oai:doaj.org-article:783878fcc1a94d1eb71fc3cc69bea8342021-11-25T06:24:38ZBenfluorex and unexplained valvular heart disease: a case-control study.1932-620310.1371/journal.pone.0010128https://doaj.org/article/783878fcc1a94d1eb71fc3cc69bea8342010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20405030/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation.<h4>Methods</h4>We conducted a case-control study. Eligible patients were those admitted in the cardiology or the cardiac surgery units of our hospital between January, 1(st) 2003 and June 30(th) 2009, with mitral insufficiency diagnostic codes (ICD-10 I340 and I051). Patients with either a primary cause (degenerative, known rheumatic heart disease, infectious endocarditis, congenital, radiation-induced valvular disease, associated connective and/or vasculitis disease, trauma, tumor) or a secondary (functional) cause were considered as having an "explained" mitral regurgitation. Other patients were considered as having an "unexplained" mitral regurgitation and were included as cases. For each case, two controls were matched for gender and for the closest date of birth, among a list of patients with an "explained" mitral regurgitation. Drug exposures were assessed blindly regarding the case or control status, through contacts with patients, their family and/or their physicians.<h4>Results</h4>Out of the 682 eligible patients, 27 cases and 54 matched controls were identified. The use of benfluorex was reported in 22 patients: 19 of the 27 cases, versus 3 of the 54 controls, odds-ratio 17.1 (3.5 to 83), adjusted for body mass index, diabetes and dexfenfluramine use.<h4>Conclusion</h4>The use of benfluorex is associated with unexplained mitral regurgitation.Irène FrachonYves EtienneYannick JobicGrégoire Le GalMarc HumbertChristophe LeroyerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e10128 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irène Frachon Yves Etienne Yannick Jobic Grégoire Le Gal Marc Humbert Christophe Leroyer Benfluorex and unexplained valvular heart disease: a case-control study.
description	<h4>Background</h4>Recent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation.<h4>Methods</h4>We conducted a case-control study. Eligible patients were those admitted in the cardiology or the cardiac surgery units of our hospital between January, 1(st) 2003 and June 30(th) 2009, with mitral insufficiency diagnostic codes (ICD-10 I340 and I051). Patients with either a primary cause (degenerative, known rheumatic heart disease, infectious endocarditis, congenital, radiation-induced valvular disease, associated connective and/or vasculitis disease, trauma, tumor) or a secondary (functional) cause were considered as having an "explained" mitral regurgitation. Other patients were considered as having an "unexplained" mitral regurgitation and were included as cases. For each case, two controls were matched for gender and for the closest date of birth, among a list of patients with an "explained" mitral regurgitation. Drug exposures were assessed blindly regarding the case or control status, through contacts with patients, their family and/or their physicians.<h4>Results</h4>Out of the 682 eligible patients, 27 cases and 54 matched controls were identified. The use of benfluorex was reported in 22 patients: 19 of the 27 cases, versus 3 of the 54 controls, odds-ratio 17.1 (3.5 to 83), adjusted for body mass index, diabetes and dexfenfluramine use.<h4>Conclusion</h4>The use of benfluorex is associated with unexplained mitral regurgitation.
format	article
author	Irène Frachon Yves Etienne Yannick Jobic Grégoire Le Gal Marc Humbert Christophe Leroyer
author_facet	Irène Frachon Yves Etienne Yannick Jobic Grégoire Le Gal Marc Humbert Christophe Leroyer
author_sort	Irène Frachon
title	Benfluorex and unexplained valvular heart disease: a case-control study.
title_short	Benfluorex and unexplained valvular heart disease: a case-control study.
title_full	Benfluorex and unexplained valvular heart disease: a case-control study.
title_fullStr	Benfluorex and unexplained valvular heart disease: a case-control study.
title_full_unstemmed	Benfluorex and unexplained valvular heart disease: a case-control study.
title_sort	benfluorex and unexplained valvular heart disease: a case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/783878fcc1a94d1eb71fc3cc69bea834
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Benfluorex and unexplained valvular heart disease: a case-control study.

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