Immunomodulation and Regenerative Capacity of MSCs for Long-COVID

The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually...

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Autores principales:	Xin Ya Loke, Siti A. M. Imran, Gee Jun Tye, Wan Safwani Wan Kamarul Zaman, Fazlina Nordin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MSCs long-COVID immunomodulation regeneration Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/783949d0e4524b7cba72c0aff69fefcf
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spelling	oai:doaj.org-article:783949d0e4524b7cba72c0aff69fefcf2021-11-25T17:56:30ZImmunomodulation and Regenerative Capacity of MSCs for Long-COVID10.3390/ijms2222124211422-00671661-6596https://doaj.org/article/783949d0e4524b7cba72c0aff69fefcf2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12421https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually death. Mesenchymal stem cells (MSCs) might prove to be a treatment option as they have immunomodulation and regenerative properties. Clinical trials utilizing MSCs in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have provided a basis in treating post-COVID-19 patients. In this review, we discussed the effects of MSCs as an immunomodulator to reduce the severity and death in patients with COVID-19, including the usage of MSCs as an alternative regenerative therapy in post-COVID-19 patients. This review also includes the current clinical trials in utilizing MSCs and their potential future utilization for long-COVID treatments.Xin Ya LokeSiti A. M. ImranGee Jun TyeWan Safwani Wan Kamarul ZamanFazlina NordinMDPI AGarticleMSCslong-COVIDimmunomodulationregenerationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12421, p 12421 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MSCs long-COVID immunomodulation regeneration Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	MSCs long-COVID immunomodulation regeneration Biology (General) QH301-705.5 Chemistry QD1-999 Xin Ya Loke Siti A. M. Imran Gee Jun Tye Wan Safwani Wan Kamarul Zaman Fazlina Nordin Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
description	The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually death. Mesenchymal stem cells (MSCs) might prove to be a treatment option as they have immunomodulation and regenerative properties. Clinical trials utilizing MSCs in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have provided a basis in treating post-COVID-19 patients. In this review, we discussed the effects of MSCs as an immunomodulator to reduce the severity and death in patients with COVID-19, including the usage of MSCs as an alternative regenerative therapy in post-COVID-19 patients. This review also includes the current clinical trials in utilizing MSCs and their potential future utilization for long-COVID treatments.
format	article
author	Xin Ya Loke Siti A. M. Imran Gee Jun Tye Wan Safwani Wan Kamarul Zaman Fazlina Nordin
author_facet	Xin Ya Loke Siti A. M. Imran Gee Jun Tye Wan Safwani Wan Kamarul Zaman Fazlina Nordin
author_sort	Xin Ya Loke
title	Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
title_short	Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
title_full	Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
title_fullStr	Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
title_full_unstemmed	Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
title_sort	immunomodulation and regenerative capacity of mscs for long-covid
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/783949d0e4524b7cba72c0aff69fefcf
work_keys_str_mv	AT xinyaloke immunomodulationandregenerativecapacityofmscsforlongcovid AT sitiamimran immunomodulationandregenerativecapacityofmscsforlongcovid AT geejuntye immunomodulationandregenerativecapacityofmscsforlongcovid AT wansafwaniwankamarulzaman immunomodulationandregenerativecapacityofmscsforlongcovid AT fazlinanordin immunomodulationandregenerativecapacityofmscsforlongcovid
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Immunomodulation and Regenerative Capacity of MSCs for Long-COVID

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