Early infection-induced natural antibody response

Abstract There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Klara Kubelkova, Tomas Hudcovic, Hana Kozakova, Jaroslav Pejchal, Ales Macela
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/783d0f22cbe14f2ab15a2718817c36e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:783d0f22cbe14f2ab15a2718817c36e4
record_format	dspace
spelling	oai:doaj.org-article:783d0f22cbe14f2ab15a2718817c36e42021-12-02T14:12:08ZEarly infection-induced natural antibody response10.1038/s41598-021-81083-02045-2322https://doaj.org/article/783d0f22cbe14f2ab15a2718817c36e42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81083-0https://doaj.org/toc/2045-2322Abstract There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens. We previously have demonstrated that Francisella interacts directly with peritoneal B-1a cells. Here, we demonstrate that, as early as 12 h postinfection, germ-free mice infected with Francisella tularensis produce infection-induced antibody clones reacting with Francisella tularensis proteins having orthologs or analogs in eukaryotic cells. Production of some individual clones was limited in time and was influenced by virulence of the Francisella strain used. The phylogenetically stabilized defense mechanism can utilize these early infection-induced antibodies both to recognize components of the invading pathogens and to eliminate molecular residues of infection-damaged self cells.Klara KubelkovaTomas HudcovicHana KozakovaJaroslav PejchalAles MacelaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Klara Kubelkova Tomas Hudcovic Hana Kozakova Jaroslav Pejchal Ales Macela Early infection-induced natural antibody response
description	Abstract There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens. We previously have demonstrated that Francisella interacts directly with peritoneal B-1a cells. Here, we demonstrate that, as early as 12 h postinfection, germ-free mice infected with Francisella tularensis produce infection-induced antibody clones reacting with Francisella tularensis proteins having orthologs or analogs in eukaryotic cells. Production of some individual clones was limited in time and was influenced by virulence of the Francisella strain used. The phylogenetically stabilized defense mechanism can utilize these early infection-induced antibodies both to recognize components of the invading pathogens and to eliminate molecular residues of infection-damaged self cells.
format	article
author	Klara Kubelkova Tomas Hudcovic Hana Kozakova Jaroslav Pejchal Ales Macela
author_facet	Klara Kubelkova Tomas Hudcovic Hana Kozakova Jaroslav Pejchal Ales Macela
author_sort	Klara Kubelkova
title	Early infection-induced natural antibody response
title_short	Early infection-induced natural antibody response
title_full	Early infection-induced natural antibody response
title_fullStr	Early infection-induced natural antibody response
title_full_unstemmed	Early infection-induced natural antibody response
title_sort	early infection-induced natural antibody response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/783d0f22cbe14f2ab15a2718817c36e4
work_keys_str_mv	AT klarakubelkova earlyinfectioninducednaturalantibodyresponse AT tomashudcovic earlyinfectioninducednaturalantibodyresponse AT hanakozakova earlyinfectioninducednaturalantibodyresponse AT jaroslavpejchal earlyinfectioninducednaturalantibodyresponse AT alesmacela earlyinfectioninducednaturalantibodyresponse
_version_	1718391851806883840

Early infection-induced natural antibody response

Ejemplares similares