Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis

Stem cells: protein not needed for stem cell activity in mammary gland A protein considered necessary for mammary stem cell activity turns out to be dispensable. What’s more, it’s not required for tumor development either. Geoffrey Wahl, Christy Trejo, and colleagues from the Salk Institute for Biol...

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Autores principales:	Christy L. Trejo, Gidsela Luna, Christopher Dravis, Benjamin T. Spike, Geoffrey M. Wahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/783e12b271884b9b9b78b908f152ebbb
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spelling	oai:doaj.org-article:783e12b271884b9b9b78b908f152ebbb2021-12-02T11:50:52ZLgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis10.1038/s41523-017-0018-62374-4677https://doaj.org/article/783e12b271884b9b9b78b908f152ebbb2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0018-6https://doaj.org/toc/2374-4677Stem cells: protein not needed for stem cell activity in mammary gland A protein considered necessary for mammary stem cell activity turns out to be dispensable. What’s more, it’s not required for tumor development either. Geoffrey Wahl, Christy Trejo, and colleagues from the Salk Institute for Biological Studies in La Jolla, CA, USA, investigated whether the expression of a protein called Lgr5 denotes mammary stem cells and whether it’s truly needed for the cells to be capable of giving rise to two cell lineages—a subject of active debate among researchers. Wahl’s team showed that mouse fetal mammary stem cells expressing Lgr5 had this dual-lineage capacity; their counterparts in the adult mouse did not. Yet, even though Lgr5 expression marks a population of fetal mammary stem cells, the protein is not required for stem cell activity or for tumors to form in a mouse model of breast cancer.Christy L. TrejoGidsela LunaChristopher DravisBenjamin T. SpikeGeoffrey M. WahlNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Christy L. Trejo Gidsela Luna Christopher Dravis Benjamin T. Spike Geoffrey M. Wahl Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
description	Stem cells: protein not needed for stem cell activity in mammary gland A protein considered necessary for mammary stem cell activity turns out to be dispensable. What’s more, it’s not required for tumor development either. Geoffrey Wahl, Christy Trejo, and colleagues from the Salk Institute for Biological Studies in La Jolla, CA, USA, investigated whether the expression of a protein called Lgr5 denotes mammary stem cells and whether it’s truly needed for the cells to be capable of giving rise to two cell lineages—a subject of active debate among researchers. Wahl’s team showed that mouse fetal mammary stem cells expressing Lgr5 had this dual-lineage capacity; their counterparts in the adult mouse did not. Yet, even though Lgr5 expression marks a population of fetal mammary stem cells, the protein is not required for stem cell activity or for tumors to form in a mouse model of breast cancer.
format	article
author	Christy L. Trejo Gidsela Luna Christopher Dravis Benjamin T. Spike Geoffrey M. Wahl
author_facet	Christy L. Trejo Gidsela Luna Christopher Dravis Benjamin T. Spike Geoffrey M. Wahl
author_sort	Christy L. Trejo
title	Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
title_short	Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
title_full	Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
title_fullStr	Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
title_full_unstemmed	Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
title_sort	lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/783e12b271884b9b9b78b908f152ebbb
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Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis

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