Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

A challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone...

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Autores principales:	Xiaojin Zhang, Yan Li, Y. Eugene Chen, Jihua Chen, Peter X. Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/783ff9bf6ea14f57b75bbdaad033b2ec
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spelling	oai:doaj.org-article:783ff9bf6ea14f57b75bbdaad033b2ec2021-12-02T17:33:20ZCell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects10.1038/ncomms103762041-1723https://doaj.org/article/783ff9bf6ea14f57b75bbdaad033b2ec2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10376https://doaj.org/toc/2041-1723A challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone defect in mice.Xiaojin ZhangYan LiY. Eugene ChenJihua ChenPeter X. MaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaojin Zhang Yan Li Y. Eugene Chen Jihua Chen Peter X. Ma Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
description	A challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone defect in mice.
format	article
author	Xiaojin Zhang Yan Li Y. Eugene Chen Jihua Chen Peter X. Ma
author_facet	Xiaojin Zhang Yan Li Y. Eugene Chen Jihua Chen Peter X. Ma
author_sort	Xiaojin Zhang
title	Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_short	Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_full	Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_fullStr	Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_full_unstemmed	Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_sort	cell-free 3d scaffold with two-stage delivery of mirna-26a to regenerate critical-sized bone defects
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/783ff9bf6ea14f57b75bbdaad033b2ec
work_keys_str_mv	AT xiaojinzhang cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects AT yanli cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects AT yeugenechen cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects AT jihuachen cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects AT peterxma cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects
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Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

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