The <italic toggle="yes">Plasmodium falciparum</italic> Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

Código QR

The <italic toggle="yes">Plasmodium falciparum</italic> Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin encodes the μ subunit of the AP-2 adaptin trafficking...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Plasmodium falciparum adaptin trafficking complex artemisinin susceptibility adaptor proteins endocytosis malaria Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/783ffd262b134205b1f7de614ed72d61
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

<named-content content-type="genus-species">Plasmodium berghei</named-content> K13 Mutations Mediate <italic toggle="yes">In Vivo</italic> Artemisinin Resistance That Is Reversed by Proteasome Inhibition
por: Nelson V. Simwela, et al.
Publicado: (2020)

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
por: Tutun Hidayet, et al.
Publicado: (2019)

Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis
por: Want MY, et al.
Publicado: (2017)

Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum
por: Robin Schumann, et al.
Publicado: (2021)

<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>
por: Judith Straimer, et al.
Publicado: (2017)

In Vitro Adventitious Regeneration of <i>Artemisia annua</i> L. Influencing Artemisinin Metabolism
por: Federica Blando, et al.
Publicado: (2021)

Absence of Plasmodium falciparum artemisinin resistance gene mutations eleven years after the adoption of artemisinin-based combination therapy in Nigeria
por: Moses Ikegbunam, et al.
Publicado: (2021)

Artemisinin Loaded mPEG-PCL Nanoparticle Based Photosensitive Gelatin Methacrylate Hydrogels for the Treatment of Gentamicin Induced Hearing Loss
por: Li X, et al.
Publicado: (2020)

Effectivity Of Annona Muricata and Artemisinin Combined Therapy on Brain CXCL10 expression (Study in Swiss Mice During Severe Plasmodium Berghei ANKA Infection)
por: Abdulhakim Sulayman, et al.
Publicado: (2019)

<named-content content-type="genus-species">Candida albicans</named-content> <italic toggle="yes">rvs161</italic>Δ and <italic toggle="yes">rvs167</italic>Δ Endocytosis Mutants Are Defective in Invasion into the Oral Cavity
por: Shamoon Naseem, et al.
Publicado: (2019)

Artemisinin Binds and Inhibits the Activity of <i>Plasmodium falciparum</i> Ddi1, a Retroviral Aspartyl Protease
por: Noah Machuki Onchieku, et al.
Publicado: (2021)

A Variant PfCRT Isoform Can Contribute to <italic toggle="yes">Plasmodium falciparum</italic> Resistance to the First-Line Partner Drug Piperaquine
por: Satish K. Dhingra, et al.
Publicado: (2017)

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle
por: Helenita C. Quadros, et al.
Publicado: (2021)

Endocytic Markers Associated with the Internalization and Processing of <italic toggle="yes">Aspergillus fumigatus</italic> Conidia by BEAS-2B Cells
por: Helen R. Clark, et al.
Publicado: (2019)

Recruitment of Host Nuclear Pore Components to the Vicinity of <italic toggle="yes">Theileria</italic> Schizonts
por: Sandra Huber, et al.
Publicado: (2020)

Fusion of clathrin and caveolae endocytic vesicles revealed by line-switching dual-color STED microscopy
por: Hefei Ruan, et al.
Publicado: (2021)

Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
por: Afolabi Owoloye, et al.
Publicado: (2021)

Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
por: Deeptashree Nandi, et al.
Publicado: (2021)

Role of <named-content content-type="genus-species">Plasmodium falciparum</named-content> Kelch 13 Protein Mutations in <named-content content-type="genus-species">P. falciparum</named-content> Populations from Northeastern Myanmar in Mediating Artemisinin Resistance
por: Faiza Amber Siddiqui, et al.
Publicado: (2020)

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
por: Peter Järver, et al.
Publicado: (2018)

Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP in <named-content content-type="genus-species">Streptococcus mutans</named-content>
por: Biswanath Jana, et al.
Publicado: (2016)

Both Clathrin-Mediated and Membrane Microdomain-Associated Endocytosis Contribute to the Cellular Adaptation to Hyperosmotic Stress in <i>Arabidopsis</i>
por: Zheng Wu, et al.
Publicado: (2021)

ISG15 Connects Autophagy and IFN-γ-Dependent Control of <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection in Human Cells
por: Jaya Bhushan, et al.
Publicado: (2020)

Uptake of DNA by cancer cells without a transfection reagent
por: Kong,Yanping, et al.
Publicado: (2017)

Enfermedad inflamatoria intestinal: Una mirada inmunológica
por: Sepúlveda,Sofía E, et al.
Publicado: (2008)

A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>
por: Gaurav Bairwa, et al.
Publicado: (2020)

The Microtubule-Stabilizing Protein CLASP1 Associates with the <italic toggle="yes">Theileria annulata</italic> Schizont Surface via Its Kinetochore-Binding Domain
por: Sandra Huber, et al.
Publicado: (2017)

Streptolysin O Inhibits Clathrin-Dependent Internalization of Group A <italic toggle="yes">Streptococcus</italic>
por: Lauren K. Logsdon, et al.
Publicado: (2011)

Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae
por: Vásquez-Soto,Beatriz, et al.
Publicado: (2015)

Immunohistochemical Evaluation of Adaptor Protein FAM159B Expression in Normal and Neoplastic Human Tissues
por: Anna-Sophia Lieselott Beyer, et al.
Publicado: (2021)

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release
por: Fei Xiao, et al.
Publicado: (2018)

Erratum for Huber et al., “The Microtubule-Stabilizing Protein CLASP1 Associates with the <italic toggle="yes">Theileria annulata</italic> Schizont Surface via Its Kinetochore-Binding Domain”
por: Sandra Huber, et al.
Publicado: (2017)

Evaluation of the pediatric antimalarial prescriptions in a teaching hospital in Southeastern Nigeria
por: Adaobi Uchenna Mosanya
Publicado: (2021)

The Functional Characterization of TcMyoF Implicates a Family of Cytostome-Cytopharynx Targeted Myosins as Integral to the Endocytic Machinery of <named-content content-type="genus-species">Trypanosoma cruzi</named-content>
por: Nathan Michael Chasen, et al.
Publicado: (2020)

Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells
por: Chaves NL, et al.
Publicado: (2017)

<i>Plasmodium falciparum</i> Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress
por: Stephanie D. Nofal, et al.
Publicado: (2021)

Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance
por: Nnamani PO, et al.
Publicado: (2016)

Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions
por: Yu Wenmin, et al.
Publicado: (2021)

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers
por: Sophie Nguyen, et al.
Publicado: (2017)

Functional Autophagic Flux Regulates AgNP Uptake And The Internalized Nanoparticles Determine Tumor Cell Fate By Temporally Regulating Flux
por: Fageria L, et al.
Publicado: (2019)