The <italic toggle="yes">Plasmodium falciparum</italic> Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

QR Code

The <italic toggle="yes">Plasmodium falciparum</italic> Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin encodes the μ subunit of the AP-2 adaptin trafficking...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2020
Sujets:	Plasmodium falciparum adaptin trafficking complex artemisinin susceptibility adaptor proteins endocytosis malaria Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/783ffd262b134205b1f7de614ed72d61
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

<named-content content-type="genus-species">Plasmodium berghei</named-content> K13 Mutations Mediate <italic toggle="yes">In Vivo</italic> Artemisinin Resistance That Is Reversed by Proteasome Inhibition
par: Nelson V. Simwela, et autres
Publié: (2020)

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
par: Tutun Hidayet, et autres
Publié: (2019)

Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis
par: Want MY, et autres
Publié: (2017)

Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum
par: Robin Schumann, et autres
Publié: (2021)

<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>
par: Judith Straimer, et autres
Publié: (2017)

In Vitro Adventitious Regeneration of <i>Artemisia annua</i> L. Influencing Artemisinin Metabolism
par: Federica Blando, et autres
Publié: (2021)

Absence of Plasmodium falciparum artemisinin resistance gene mutations eleven years after the adoption of artemisinin-based combination therapy in Nigeria
par: Moses Ikegbunam, et autres
Publié: (2021)

Artemisinin Loaded mPEG-PCL Nanoparticle Based Photosensitive Gelatin Methacrylate Hydrogels for the Treatment of Gentamicin Induced Hearing Loss
par: Li X, et autres
Publié: (2020)

Effectivity Of Annona Muricata and Artemisinin Combined Therapy on Brain CXCL10 expression (Study in Swiss Mice During Severe Plasmodium Berghei ANKA Infection)
par: Abdulhakim Sulayman, et autres
Publié: (2019)

<named-content content-type="genus-species">Candida albicans</named-content> <italic toggle="yes">rvs161</italic>Δ and <italic toggle="yes">rvs167</italic>Δ Endocytosis Mutants Are Defective in Invasion into the Oral Cavity
par: Shamoon Naseem, et autres
Publié: (2019)

Artemisinin Binds and Inhibits the Activity of <i>Plasmodium falciparum</i> Ddi1, a Retroviral Aspartyl Protease
par: Noah Machuki Onchieku, et autres
Publié: (2021)

A Variant PfCRT Isoform Can Contribute to <italic toggle="yes">Plasmodium falciparum</italic> Resistance to the First-Line Partner Drug Piperaquine
par: Satish K. Dhingra, et autres
Publié: (2017)

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle
par: Helenita C. Quadros, et autres
Publié: (2021)

Endocytic Markers Associated with the Internalization and Processing of <italic toggle="yes">Aspergillus fumigatus</italic> Conidia by BEAS-2B Cells
par: Helen R. Clark, et autres
Publié: (2019)

Recruitment of Host Nuclear Pore Components to the Vicinity of <italic toggle="yes">Theileria</italic> Schizonts
par: Sandra Huber, et autres
Publié: (2020)

Fusion of clathrin and caveolae endocytic vesicles revealed by line-switching dual-color STED microscopy
par: Hefei Ruan, et autres
Publié: (2021)

Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
par: Afolabi Owoloye, et autres
Publié: (2021)

Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
par: Deeptashree Nandi, et autres
Publié: (2021)

Role of <named-content content-type="genus-species">Plasmodium falciparum</named-content> Kelch 13 Protein Mutations in <named-content content-type="genus-species">P. falciparum</named-content> Populations from Northeastern Myanmar in Mediating Artemisinin Resistance
par: Faiza Amber Siddiqui, et autres
Publié: (2020)

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
par: Peter Järver, et autres
Publié: (2018)

Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP in <named-content content-type="genus-species">Streptococcus mutans</named-content>
par: Biswanath Jana, et autres
Publié: (2016)

Both Clathrin-Mediated and Membrane Microdomain-Associated Endocytosis Contribute to the Cellular Adaptation to Hyperosmotic Stress in <i>Arabidopsis</i>
par: Zheng Wu, et autres
Publié: (2021)

ISG15 Connects Autophagy and IFN-γ-Dependent Control of <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection in Human Cells
par: Jaya Bhushan, et autres
Publié: (2020)

Uptake of DNA by cancer cells without a transfection reagent
par: Kong,Yanping, et autres
Publié: (2017)

Enfermedad inflamatoria intestinal: Una mirada inmunológica
par: Sepúlveda,Sofía E, et autres
Publié: (2008)

A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>
par: Gaurav Bairwa, et autres
Publié: (2020)

The Microtubule-Stabilizing Protein CLASP1 Associates with the <italic toggle="yes">Theileria annulata</italic> Schizont Surface via Its Kinetochore-Binding Domain
par: Sandra Huber, et autres
Publié: (2017)

Streptolysin O Inhibits Clathrin-Dependent Internalization of Group A <italic toggle="yes">Streptococcus</italic>
par: Lauren K. Logsdon, et autres
Publié: (2011)

Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae
par: Vásquez-Soto,Beatriz, et autres
Publié: (2015)

Immunohistochemical Evaluation of Adaptor Protein FAM159B Expression in Normal and Neoplastic Human Tissues
par: Anna-Sophia Lieselott Beyer, et autres
Publié: (2021)

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release
par: Fei Xiao, et autres
Publié: (2018)

Erratum for Huber et al., “The Microtubule-Stabilizing Protein CLASP1 Associates with the <italic toggle="yes">Theileria annulata</italic> Schizont Surface via Its Kinetochore-Binding Domain”
par: Sandra Huber, et autres
Publié: (2017)

Evaluation of the pediatric antimalarial prescriptions in a teaching hospital in Southeastern Nigeria
par: Adaobi Uchenna Mosanya
Publié: (2021)

The Functional Characterization of TcMyoF Implicates a Family of Cytostome-Cytopharynx Targeted Myosins as Integral to the Endocytic Machinery of <named-content content-type="genus-species">Trypanosoma cruzi</named-content>
par: Nathan Michael Chasen, et autres
Publié: (2020)

Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells
par: Chaves NL, et autres
Publié: (2017)

<i>Plasmodium falciparum</i> Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress
par: Stephanie D. Nofal, et autres
Publié: (2021)

Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance
par: Nnamani PO, et autres
Publié: (2016)

Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions
par: Yu Wenmin, et autres
Publié: (2021)

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers
par: Sophie Nguyen, et autres
Publié: (2017)

Functional Autophagic Flux Regulates AgNP Uptake And The Internalized Nanoparticles Determine Tumor Cell Fate By Temporally Regulating Flux
par: Fageria L, et autres
Publié: (2019)