A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula

Abstract Traditional Chinese medicine (TCM), such as Uyghur Medicine (UM) has been used in clinical treatment for many years. TCM is featured as multiple targets and complex mechanisms of action, which is normally a combination of medicinal herbs and sometimes even contains certain rare animal medic...

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Autores principales:	Jinghui Wang, Yan Li, Yinfeng Yang, Xuetong Chen, Jian Du, Qiusheng Zheng, Zongsuo Liang, Yonghua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78479e18097b474aafe7e6de9c40b58b
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spelling	oai:doaj.org-article:78479e18097b474aafe7e6de9c40b58b2021-12-02T15:05:53ZA New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula10.1038/s41598-017-01613-72045-2322https://doaj.org/article/78479e18097b474aafe7e6de9c40b58b2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01613-7https://doaj.org/toc/2045-2322Abstract Traditional Chinese medicine (TCM), such as Uyghur Medicine (UM) has been used in clinical treatment for many years. TCM is featured as multiple targets and complex mechanisms of action, which is normally a combination of medicinal herbs and sometimes even contains certain rare animal medicinal ingredients. A question arises as to whether these animal materials can be removed replaced from TCM applications due to their valuable rare resources or animal ethics. Here, we select a classical UM Yimusake formula, which contains 3 animal drugs and other 8 herbs, and has got wealthy experience and remarkable achievements in treating erectile dysfunction (ED) in China. The active components, drug targets and therapeutic mechanisms have been comprehensively analyzed by systems-pharmacology methods. Additionally, to validate the inhibitory effects of all candidate compounds on their related targets, in vitro experiments, computational analysis and molecular dynamics simulations were performed. The results show that the modified, original and three animal materials display very similar mechanisms for an effective treatment of ED, indicating that it is quite possible to remove these three animal drugs from the original formula while still keep its efficiency. This work provides a new attempt for deleting animal materials from TCM, which should be important for optimization of traditional medicines.Jinghui WangYan LiYinfeng YangXuetong ChenJian DuQiusheng ZhengZongsuo LiangYonghua WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-22 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinghui Wang Yan Li Yinfeng Yang Xuetong Chen Jian Du Qiusheng Zheng Zongsuo Liang Yonghua Wang A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
description	Abstract Traditional Chinese medicine (TCM), such as Uyghur Medicine (UM) has been used in clinical treatment for many years. TCM is featured as multiple targets and complex mechanisms of action, which is normally a combination of medicinal herbs and sometimes even contains certain rare animal medicinal ingredients. A question arises as to whether these animal materials can be removed replaced from TCM applications due to their valuable rare resources or animal ethics. Here, we select a classical UM Yimusake formula, which contains 3 animal drugs and other 8 herbs, and has got wealthy experience and remarkable achievements in treating erectile dysfunction (ED) in China. The active components, drug targets and therapeutic mechanisms have been comprehensively analyzed by systems-pharmacology methods. Additionally, to validate the inhibitory effects of all candidate compounds on their related targets, in vitro experiments, computational analysis and molecular dynamics simulations were performed. The results show that the modified, original and three animal materials display very similar mechanisms for an effective treatment of ED, indicating that it is quite possible to remove these three animal drugs from the original formula while still keep its efficiency. This work provides a new attempt for deleting animal materials from TCM, which should be important for optimization of traditional medicines.
format	article
author	Jinghui Wang Yan Li Yinfeng Yang Xuetong Chen Jian Du Qiusheng Zheng Zongsuo Liang Yonghua Wang
author_facet	Jinghui Wang Yan Li Yinfeng Yang Xuetong Chen Jian Du Qiusheng Zheng Zongsuo Liang Yonghua Wang
author_sort	Jinghui Wang
title	A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
title_short	A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
title_full	A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
title_fullStr	A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
title_full_unstemmed	A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
title_sort	new strategy for deleting animal drugs from traditional chinese medicines based on modified yimusake formula
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78479e18097b474aafe7e6de9c40b58b
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A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula

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