Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>

ABSTRACT Outer membrane biogenesis is a complex process for Gram-negative bacteria as the components are synthesized in the cytoplasm or at the inner membrane and then transported to the outer membrane. Stress pathways monitor and respond to problems encountered in assembling the outer membrane. The...

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Autores principales:	Brent W. Simpson, M. Stephen Trent
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	CpxAR Lol NlpE Rcs copper lipoproteins Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/784b8aece8ce4820bb9394d5aeca9a12
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spelling	oai:doaj.org-article:784b8aece8ce4820bb9394d5aeca9a122021-11-15T15:55:25ZEmerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>10.1128/mBio.01302-192150-7511https://doaj.org/article/784b8aece8ce4820bb9394d5aeca9a122019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01302-19https://doaj.org/toc/2150-7511ABSTRACT Outer membrane biogenesis is a complex process for Gram-negative bacteria as the components are synthesized in the cytoplasm or at the inner membrane and then transported to the outer membrane. Stress pathways monitor and respond to problems encountered in assembling the outer membrane. The two-component system CpxAR was recently reported to be a stress pathway for transport of lipoproteins to the outer membrane, but it was unclear how this stress is sensed. May et al. [K. L. May, K. M. Lehman, A. M. Mitchell, and M. Grabowicz, mBio 10(3):e00618-19, 2019, https://doi.org/10.1128/mBio.00618-19] determined that an outer membrane lipoprotein, NlpE, is the sensor for lipoprotein biogenesis stress. The group demonstrated that CpxAR is activated by the N-terminal domain of NlpE when the lipoprotein accumulates at the inner membrane. Further, this work resolved a previously debated role for NlpE in sensing copper stress; copper was shown to inhibit acylation of lipoproteins, preventing them from being transported to the outer membrane.Brent W. SimpsonM. Stephen TrentAmerican Society for MicrobiologyarticleCpxARLolNlpERcscopperlipoproteinsMicrobiologyQR1-502ENmBio, Vol 10, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	CpxAR Lol NlpE Rcs copper lipoproteins Microbiology QR1-502
spellingShingle	CpxAR Lol NlpE Rcs copper lipoproteins Microbiology QR1-502 Brent W. Simpson M. Stephen Trent Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>
description	ABSTRACT Outer membrane biogenesis is a complex process for Gram-negative bacteria as the components are synthesized in the cytoplasm or at the inner membrane and then transported to the outer membrane. Stress pathways monitor and respond to problems encountered in assembling the outer membrane. The two-component system CpxAR was recently reported to be a stress pathway for transport of lipoproteins to the outer membrane, but it was unclear how this stress is sensed. May et al. [K. L. May, K. M. Lehman, A. M. Mitchell, and M. Grabowicz, mBio 10(3):e00618-19, 2019, https://doi.org/10.1128/mBio.00618-19] determined that an outer membrane lipoprotein, NlpE, is the sensor for lipoprotein biogenesis stress. The group demonstrated that CpxAR is activated by the N-terminal domain of NlpE when the lipoprotein accumulates at the inner membrane. Further, this work resolved a previously debated role for NlpE in sensing copper stress; copper was shown to inhibit acylation of lipoproteins, preventing them from being transported to the outer membrane.
format	article
author	Brent W. Simpson M. Stephen Trent
author_facet	Brent W. Simpson M. Stephen Trent
author_sort	Brent W. Simpson
title	Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>
title_short	Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>
title_full	Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>
title_fullStr	Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>
title_full_unstemmed	Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>
title_sort	emerging roles for nlpe as a sensor for lipoprotein maturation and transport to the outer membrane in <named-content content-type="genus-species">escherichia coli</named-content>
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/784b8aece8ce4820bb9394d5aeca9a12
work_keys_str_mv	AT brentwsimpson emergingrolesfornlpeasasensorforlipoproteinmaturationandtransporttotheoutermembraneinnamedcontentcontenttypegenusspeciesescherichiacolinamedcontent AT mstephentrent emergingrolesfornlpeasasensorforlipoproteinmaturationandtransporttotheoutermembraneinnamedcontentcontenttypegenusspeciesescherichiacolinamedcontent
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Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in <named-content content-type="genus-species">Escherichia coli</named-content>

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