Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ
Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes perturb myoepithelial function in DCIS to promote i...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/784cf49197cf4d50824d3974f6c39d75 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:784cf49197cf4d50824d3974f6c39d75 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:784cf49197cf4d50824d3974f6c39d752021-12-02T17:01:33ZPerturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ10.1038/s41467-019-12125-52041-1723https://doaj.org/article/784cf49197cf4d50824d3974f6c39d752019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12125-5https://doaj.org/toc/2041-1723Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes perturb myoepithelial function in DCIS to promote invasive progression.Lina DingYing SuAnne FasslKunihiko HinoharaXintao QiuNicholas W. HarperSung Jin HuhNoga Bloushtain-QimronBojana JovanovićMuhammad EkramXiaoyuan ZiWilliam C. HinesMaša AlečkovićCarlos Gil del AlcazarRyan J. CaulfieldDennis M. BonalQuang-De NguyenVanessa F. MerinoSibgat ChoudhuryGabrielle EthingtonLaura PanosMichael GrantWilliam HerlihyAlfred AuGedge D. RossonPedram ArganiAndrea L. RichardsonDeborah DillonD. Craig AllredKirsten BabskiElizabeth Min Hui KimCharles H. McDonnellJon WagnerRon RowberryKristie BobolisCelina G. KleerE. Shelley HwangJoanne L. BlumSimona CristeaPiotr SicinskiRong FanHenry W. LongSaraswati SukumarSo Yeon ParkJudy E. GarberMina BissellJun YaoKornelia PolyakNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lina Ding Ying Su Anne Fassl Kunihiko Hinohara Xintao Qiu Nicholas W. Harper Sung Jin Huh Noga Bloushtain-Qimron Bojana Jovanović Muhammad Ekram Xiaoyuan Zi William C. Hines Maša Alečković Carlos Gil del Alcazar Ryan J. Caulfield Dennis M. Bonal Quang-De Nguyen Vanessa F. Merino Sibgat Choudhury Gabrielle Ethington Laura Panos Michael Grant William Herlihy Alfred Au Gedge D. Rosson Pedram Argani Andrea L. Richardson Deborah Dillon D. Craig Allred Kirsten Babski Elizabeth Min Hui Kim Charles H. McDonnell Jon Wagner Ron Rowberry Kristie Bobolis Celina G. Kleer E. Shelley Hwang Joanne L. Blum Simona Cristea Piotr Sicinski Rong Fan Henry W. Long Saraswati Sukumar So Yeon Park Judy E. Garber Mina Bissell Jun Yao Kornelia Polyak Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ |
| description |
Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes perturb myoepithelial function in DCIS to promote invasive progression. |
| format |
article |
| author |
Lina Ding Ying Su Anne Fassl Kunihiko Hinohara Xintao Qiu Nicholas W. Harper Sung Jin Huh Noga Bloushtain-Qimron Bojana Jovanović Muhammad Ekram Xiaoyuan Zi William C. Hines Maša Alečković Carlos Gil del Alcazar Ryan J. Caulfield Dennis M. Bonal Quang-De Nguyen Vanessa F. Merino Sibgat Choudhury Gabrielle Ethington Laura Panos Michael Grant William Herlihy Alfred Au Gedge D. Rosson Pedram Argani Andrea L. Richardson Deborah Dillon D. Craig Allred Kirsten Babski Elizabeth Min Hui Kim Charles H. McDonnell Jon Wagner Ron Rowberry Kristie Bobolis Celina G. Kleer E. Shelley Hwang Joanne L. Blum Simona Cristea Piotr Sicinski Rong Fan Henry W. Long Saraswati Sukumar So Yeon Park Judy E. Garber Mina Bissell Jun Yao Kornelia Polyak |
| author_facet |
Lina Ding Ying Su Anne Fassl Kunihiko Hinohara Xintao Qiu Nicholas W. Harper Sung Jin Huh Noga Bloushtain-Qimron Bojana Jovanović Muhammad Ekram Xiaoyuan Zi William C. Hines Maša Alečković Carlos Gil del Alcazar Ryan J. Caulfield Dennis M. Bonal Quang-De Nguyen Vanessa F. Merino Sibgat Choudhury Gabrielle Ethington Laura Panos Michael Grant William Herlihy Alfred Au Gedge D. Rosson Pedram Argani Andrea L. Richardson Deborah Dillon D. Craig Allred Kirsten Babski Elizabeth Min Hui Kim Charles H. McDonnell Jon Wagner Ron Rowberry Kristie Bobolis Celina G. Kleer E. Shelley Hwang Joanne L. Blum Simona Cristea Piotr Sicinski Rong Fan Henry W. Long Saraswati Sukumar So Yeon Park Judy E. Garber Mina Bissell Jun Yao Kornelia Polyak |
| author_sort |
Lina Ding |
| title |
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ |
| title_short |
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ |
| title_full |
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ |
| title_fullStr |
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ |
| title_full_unstemmed |
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ |
| title_sort |
perturbed myoepithelial cell differentiation in brca mutation carriers and in ductal carcinoma in situ |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/784cf49197cf4d50824d3974f6c39d75 |
| work_keys_str_mv |
AT linading perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT yingsu perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT annefassl perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT kunihikohinohara perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT xintaoqiu perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT nicholaswharper perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT sungjinhuh perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT nogabloushtainqimron perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT bojanajovanovic perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT muhammadekram perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT xiaoyuanzi perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT williamchines perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT masaaleckovic perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT carlosgildelalcazar perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT ryanjcaulfield perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT dennismbonal perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT quangdenguyen perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT vanessafmerino perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT sibgatchoudhury perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT gabrielleethington perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT laurapanos perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT michaelgrant perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT williamherlihy perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT alfredau perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT gedgedrosson perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT pedramargani perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT andrealrichardson perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT deborahdillon perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT dcraigallred perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT kirstenbabski perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT elizabethminhuikim perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT charleshmcdonnell perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT jonwagner perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT ronrowberry perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT kristiebobolis perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT celinagkleer perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT eshelleyhwang perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT joannelblum perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT simonacristea perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT piotrsicinski perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT rongfan perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT henrywlong perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT saraswatisukumar perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT soyeonpark perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT judyegarber perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT minabissell perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT junyao perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu AT korneliapolyak perturbedmyoepithelialcelldifferentiationinbrcamutationcarriersandinductalcarcinomainsitu |
| _version_ |
1718382090605559808 |