Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study

Chunxiao Liao,1 Wenjing Gao,1 Weihua Cao,1 Jun Lv,1 Canqing Yu,1 Shengfeng Wang,1 Zengchang Pang,2 Liming Cong,3 Hua Wang,4 Xianping Wu,5 Liming Li1 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, People’s Republic of China; 2Qing...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liao C, Gao W, Cao W, Lv J, Yu C, Wang S, Pang Z, Cong L, Wang H, Wu X, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	metabolic status insulin resistance inflammation twin study Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/7851eecacf5c4d89ab34096074eff6c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7851eecacf5c4d89ab34096074eff6c9
record_format	dspace
spelling	oai:doaj.org-article:7851eecacf5c4d89ab34096074eff6c92021-12-02T13:34:18ZAssociations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study1178-7007https://doaj.org/article/7851eecacf5c4d89ab34096074eff6c92021-03-01T00:00:00Zhttps://www.dovepress.com/associations-of-metabolicobesity-phenotypes-with-insulin-resistance-an-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Chunxiao Liao,1 Wenjing Gao,1 Weihua Cao,1 Jun Lv,1 Canqing Yu,1 Shengfeng Wang,1 Zengchang Pang,2 Liming Cong,3 Hua Wang,4 Xianping Wu,5 Liming Li1 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, People’s Republic of China; 2Qingdao Center for Diseases Control and Prevention, Qingdao, 266033, People’s Republic of China; 3Zhejiang Center for Disease Control and Prevention, Hangzhou, 310051, People’s Republic of China; 4Jiangsu Center for Disease Control and Prevention, Nanjing, 210009, People’s Republic of China; 5Sichuan Center for Disease Control and Prevention, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Liming Li; Wenjing GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 XueYuan Road, HaiDian District, Beijing, 100191, People’s Republic of ChinaTel +86 10 82801528Fax +86 10 82801528 Ext. 322Email lmlee@vip.163.com; wenjinggao@bjmu.edu.cnBackground: Obesity is a heterogeneous condition in terms of metabolic status. Different obesity phenotypes have various health risks. The aim of this work was to define different subtypes of obesity and investigate their relationship with inflammatory-cardiometabolic abnormalities among Chinese adult twins.Methods: The analyses used data from 1113 adult twins in 4 provinces (Shandong, Zhejiang, Jiangsu and Sichuan) from Chinese National Twin Registry (CNTR) which collected detailed information. We defined those with 0 or 1 metabolic syndrome (MetS) components excluding waist circumference as metabolically healthy, and those with waist circumference ≥ 90 cm (for men) and ≥ 85 cm (for women) as obese. The two-category obesity status and metabolic states are combined to generate four metabolic/obesity phenotypes. High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as surrogate measure of insulin resistance. Mixed-effect linear regression models and fixed-effect linear regression models were used to analyse the correlation between HOMA-IR, hsCRP and different metabolic/obesity phenotypes.Results: In cross-sectional analyses of 1113 individuals (mean [SD] age, 46.6 [12.9] years; 463 obese [41.6%]), 20.3% obese twins were metabolic healthy and 64.2% non-obese twins were metabolic unhealthy. Serum HOMA-IR level was higher in metabolically unhealthy non-obesity (MUNO) (β=0.42, 95% CI: 0.21– 0.64), metabolically healthy obesity (MHO) (β=0.68, 95% CI: 0.36– 1.00) and metabolically unhealthy obesity (MUO) (β=0.69, 95% CI: 0.46– 0.91) twins, compared with their metabolically healthy non-obesity (MHNO) counterparts. HsCRP was similar between MHO and MUO, which differed significantly to metabolic healthy non-obesity (MHNO).Conclusion: MHO and MUNO phenotypes were common in Chinese twin population. Both phenotypes were associated with elevated IR and hsCRP which may not be benign and need to be concerned.Keywords: metabolic status, insulin resistance, chronic inflammation, twin studyLiao CGao WCao WLv JYu CWang SPang ZCong LWang HWu XLi LDove Medical Pressarticlemetabolic statusinsulin resistanceinflammationtwin studySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1141-1151 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic status insulin resistance inflammation twin study Specialties of internal medicine RC581-951
spellingShingle	metabolic status insulin resistance inflammation twin study Specialties of internal medicine RC581-951 Liao C Gao W Cao W Lv J Yu C Wang S Pang Z Cong L Wang H Wu X Li L Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study
description	Chunxiao Liao,1 Wenjing Gao,1 Weihua Cao,1 Jun Lv,1 Canqing Yu,1 Shengfeng Wang,1 Zengchang Pang,2 Liming Cong,3 Hua Wang,4 Xianping Wu,5 Liming Li1 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, People’s Republic of China; 2Qingdao Center for Diseases Control and Prevention, Qingdao, 266033, People’s Republic of China; 3Zhejiang Center for Disease Control and Prevention, Hangzhou, 310051, People’s Republic of China; 4Jiangsu Center for Disease Control and Prevention, Nanjing, 210009, People’s Republic of China; 5Sichuan Center for Disease Control and Prevention, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Liming Li; Wenjing GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 XueYuan Road, HaiDian District, Beijing, 100191, People’s Republic of ChinaTel +86 10 82801528Fax +86 10 82801528 Ext. 322Email lmlee@vip.163.com; wenjinggao@bjmu.edu.cnBackground: Obesity is a heterogeneous condition in terms of metabolic status. Different obesity phenotypes have various health risks. The aim of this work was to define different subtypes of obesity and investigate their relationship with inflammatory-cardiometabolic abnormalities among Chinese adult twins.Methods: The analyses used data from 1113 adult twins in 4 provinces (Shandong, Zhejiang, Jiangsu and Sichuan) from Chinese National Twin Registry (CNTR) which collected detailed information. We defined those with 0 or 1 metabolic syndrome (MetS) components excluding waist circumference as metabolically healthy, and those with waist circumference ≥ 90 cm (for men) and ≥ 85 cm (for women) as obese. The two-category obesity status and metabolic states are combined to generate four metabolic/obesity phenotypes. High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as surrogate measure of insulin resistance. Mixed-effect linear regression models and fixed-effect linear regression models were used to analyse the correlation between HOMA-IR, hsCRP and different metabolic/obesity phenotypes.Results: In cross-sectional analyses of 1113 individuals (mean [SD] age, 46.6 [12.9] years; 463 obese [41.6%]), 20.3% obese twins were metabolic healthy and 64.2% non-obese twins were metabolic unhealthy. Serum HOMA-IR level was higher in metabolically unhealthy non-obesity (MUNO) (β=0.42, 95% CI: 0.21– 0.64), metabolically healthy obesity (MHO) (β=0.68, 95% CI: 0.36– 1.00) and metabolically unhealthy obesity (MUO) (β=0.69, 95% CI: 0.46– 0.91) twins, compared with their metabolically healthy non-obesity (MHNO) counterparts. HsCRP was similar between MHO and MUO, which differed significantly to metabolic healthy non-obesity (MHNO).Conclusion: MHO and MUNO phenotypes were common in Chinese twin population. Both phenotypes were associated with elevated IR and hsCRP which may not be benign and need to be concerned.Keywords: metabolic status, insulin resistance, chronic inflammation, twin study
format	article
author	Liao C Gao W Cao W Lv J Yu C Wang S Pang Z Cong L Wang H Wu X Li L
author_facet	Liao C Gao W Cao W Lv J Yu C Wang S Pang Z Cong L Wang H Wu X Li L
author_sort	Liao C
title	Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study
title_short	Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study
title_full	Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study
title_fullStr	Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study
title_full_unstemmed	Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study
title_sort	associations of metabolic/obesity phenotypes with insulin resistance and c-reactive protein: results from the cntr study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7851eecacf5c4d89ab34096074eff6c9
work_keys_str_mv	AT liaoc associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT gaow associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT caow associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT lvj associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT yuc associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT wangs associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT pangz associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT congl associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT wangh associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT wux associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy AT lil associationsofmetabolicobesityphenotypeswithinsulinresistanceandcreactiveproteinresultsfromthecntrstudy
_version_	1718392803536404480

Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study

Ejemplares similares