A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance esca...

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Autores principales:	Paola A. Betancur, Brian J. Abraham, Ying Y. Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark Zarnegar, Angera H. Kuo, Kelly McKenna, Yoko Kojima, Nicholas J. Leeper, Po Ho, Phung Gip, Tomek Swigut, Richard I. Sherwood, Michael F. Clarke, George Somlo, Richard A. Young, Irving L. Weissman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78521d1c01db4a828a254b9785273b10
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spelling	oai:doaj.org-article:78521d1c01db4a828a254b9785273b102021-12-02T14:42:40ZA CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer10.1038/ncomms148022041-1723https://doaj.org/article/78521d1c01db4a828a254b9785273b102017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14802https://doaj.org/toc/2041-1723Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance escape.Paola A. BetancurBrian J. AbrahamYing Y. YiuStephen B. WillinghamFarnaz KhamenehMark ZarnegarAngera H. KuoKelly McKennaYoko KojimaNicholas J. LeeperPo HoPhung GipTomek SwigutRichard I. SherwoodMichael F. ClarkeGeorge SomloRichard A. YoungIrving L. WeissmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paola A. Betancur Brian J. Abraham Ying Y. Yiu Stephen B. Willingham Farnaz Khameneh Mark Zarnegar Angera H. Kuo Kelly McKenna Yoko Kojima Nicholas J. Leeper Po Ho Phung Gip Tomek Swigut Richard I. Sherwood Michael F. Clarke George Somlo Richard A. Young Irving L. Weissman A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
description	Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance escape.
format	article
author	Paola A. Betancur Brian J. Abraham Ying Y. Yiu Stephen B. Willingham Farnaz Khameneh Mark Zarnegar Angera H. Kuo Kelly McKenna Yoko Kojima Nicholas J. Leeper Po Ho Phung Gip Tomek Swigut Richard I. Sherwood Michael F. Clarke George Somlo Richard A. Young Irving L. Weissman
author_facet	Paola A. Betancur Brian J. Abraham Ying Y. Yiu Stephen B. Willingham Farnaz Khameneh Mark Zarnegar Angera H. Kuo Kelly McKenna Yoko Kojima Nicholas J. Leeper Po Ho Phung Gip Tomek Swigut Richard I. Sherwood Michael F. Clarke George Somlo Richard A. Young Irving L. Weissman
author_sort	Paola A. Betancur
title	A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
title_short	A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
title_full	A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
title_fullStr	A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
title_full_unstemmed	A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
title_sort	cd47-associated super-enhancer links pro-inflammatory signalling to cd47 upregulation in breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78521d1c01db4a828a254b9785273b10
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A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

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