A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance esca...

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Main Authors: Paola A. Betancur, Brian J. Abraham, Ying Y. Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark Zarnegar, Angera H. Kuo, Kelly McKenna, Yoko Kojima, Nicholas J. Leeper, Po Ho, Phung Gip, Tomek Swigut, Richard I. Sherwood, Michael F. Clarke, George Somlo, Richard A. Young, Irving L. Weissman
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/78521d1c01db4a828a254b9785273b10
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https://doaj.org/article/78521d1c01db4a828a254b9785273b10

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