The CaMKII holoenzyme structure in activation-competent conformations

Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered link...

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Autores principales:	Janette B. Myers, Vincent Zaegel, Steven J. Coultrap, Adam P. Miller, K. Ulrich Bayer, Steve L. Reichow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7852f7f279904d55b15ee9e82bae8fc7
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spelling	oai:doaj.org-article:7852f7f279904d55b15ee9e82bae8fc72021-12-02T17:06:14ZThe CaMKII holoenzyme structure in activation-competent conformations10.1038/ncomms157422041-1723https://doaj.org/article/7852f7f279904d55b15ee9e82bae8fc72017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15742https://doaj.org/toc/2041-1723Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered linker domain in facilitating cooperative activation.Janette B. MyersVincent ZaegelSteven J. CoultrapAdam P. MillerK. Ulrich BayerSteve L. ReichowNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janette B. Myers Vincent Zaegel Steven J. Coultrap Adam P. Miller K. Ulrich Bayer Steve L. Reichow The CaMKII holoenzyme structure in activation-competent conformations
description	Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered linker domain in facilitating cooperative activation.
format	article
author	Janette B. Myers Vincent Zaegel Steven J. Coultrap Adam P. Miller K. Ulrich Bayer Steve L. Reichow
author_facet	Janette B. Myers Vincent Zaegel Steven J. Coultrap Adam P. Miller K. Ulrich Bayer Steve L. Reichow
author_sort	Janette B. Myers
title	The CaMKII holoenzyme structure in activation-competent conformations
title_short	The CaMKII holoenzyme structure in activation-competent conformations
title_full	The CaMKII holoenzyme structure in activation-competent conformations
title_fullStr	The CaMKII holoenzyme structure in activation-competent conformations
title_full_unstemmed	The CaMKII holoenzyme structure in activation-competent conformations
title_sort	camkii holoenzyme structure in activation-competent conformations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7852f7f279904d55b15ee9e82bae8fc7
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The CaMKII holoenzyme structure in activation-competent conformations

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