Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses

Background: Tripartite motif containing 46 was initially identified as the oncogene in several human tumors. However, the clinical value and potential functions of tripartite motif containing 46 (TRIM46) in clear cell renal cell carcinoma (ccRCC) remained largely unclear.Methods: The expressing patt...

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Autores principales:	Xiang-bin Ren, Jing Zhao, Xue-feng Liang, Xu-dong Guo, Shao-bo Jiang, Yu-zhu Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TRIM46 clear cell renal cell carcinoma prognosis biomarker therapeutic target Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/78541caa92434ef0a576f85bf2db9c17
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spelling	oai:doaj.org-article:78541caa92434ef0a576f85bf2db9c172021-11-22T05:17:14ZIdentification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses2296-858X10.3389/fmed.2021.785331https://doaj.org/article/78541caa92434ef0a576f85bf2db9c172021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.785331/fullhttps://doaj.org/toc/2296-858XBackground: Tripartite motif containing 46 was initially identified as the oncogene in several human tumors. However, the clinical value and potential functions of tripartite motif containing 46 (TRIM46) in clear cell renal cell carcinoma (ccRCC) remained largely unclear.Methods: The expressing patterns, clinical involvement, and prognostic values of TRIM46 were analyzed using the data obtained from TCGA and GEO databases. A nomogram was constructed to examine the outcome of patients with ccRCC. We estimated the association between TRIM46 with tumor immunity in ccRCC.Results: Tripartite motif containing 46 was highly expressed in ccRCC, and its upregulation revealed an unfavorable prognosis. A nomogram based on TRIM46 expressions and other independent prognostic factors could robustly predict the overall survival of tumor patients. TRIM46 has a strong positive correlation with NUMBL, CACNB1, THBS3, ROBO3, MAP3K12, ANKRD13D, PIF1, PRELID3A, ANKRD13B, and PCNX2. Mechanically, TRIM46 displayed regulatory functions in ccRCC progression via several tumor-associated pathways. Besides, we observed that TRIM46 was distinctly related to tumor immunity in ccRCC.Conclusions: Our findings provide a novel tumor promotive role regarding TRIM46 function in the malignant progression of ccRCC.Xiang-bin RenJing ZhaoXue-feng LiangXu-dong GuoShao-bo JiangYu-zhu XiangFrontiers Media S.A.articleTRIM46clear cell renal cell carcinomaprognosisbiomarkertherapeutic targetMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRIM46 clear cell renal cell carcinoma prognosis biomarker therapeutic target Medicine (General) R5-920
spellingShingle	TRIM46 clear cell renal cell carcinoma prognosis biomarker therapeutic target Medicine (General) R5-920 Xiang-bin Ren Jing Zhao Xue-feng Liang Xu-dong Guo Shao-bo Jiang Yu-zhu Xiang Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
description	Background: Tripartite motif containing 46 was initially identified as the oncogene in several human tumors. However, the clinical value and potential functions of tripartite motif containing 46 (TRIM46) in clear cell renal cell carcinoma (ccRCC) remained largely unclear.Methods: The expressing patterns, clinical involvement, and prognostic values of TRIM46 were analyzed using the data obtained from TCGA and GEO databases. A nomogram was constructed to examine the outcome of patients with ccRCC. We estimated the association between TRIM46 with tumor immunity in ccRCC.Results: Tripartite motif containing 46 was highly expressed in ccRCC, and its upregulation revealed an unfavorable prognosis. A nomogram based on TRIM46 expressions and other independent prognostic factors could robustly predict the overall survival of tumor patients. TRIM46 has a strong positive correlation with NUMBL, CACNB1, THBS3, ROBO3, MAP3K12, ANKRD13D, PIF1, PRELID3A, ANKRD13B, and PCNX2. Mechanically, TRIM46 displayed regulatory functions in ccRCC progression via several tumor-associated pathways. Besides, we observed that TRIM46 was distinctly related to tumor immunity in ccRCC.Conclusions: Our findings provide a novel tumor promotive role regarding TRIM46 function in the malignant progression of ccRCC.
format	article
author	Xiang-bin Ren Jing Zhao Xue-feng Liang Xu-dong Guo Shao-bo Jiang Yu-zhu Xiang
author_facet	Xiang-bin Ren Jing Zhao Xue-feng Liang Xu-dong Guo Shao-bo Jiang Yu-zhu Xiang
author_sort	Xiang-bin Ren
title	Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
title_short	Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
title_full	Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
title_fullStr	Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
title_full_unstemmed	Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses
title_sort	identification trim46 as a potential biomarker and therapeutic target for clear cell renal cell carcinoma through comprehensive bioinformatics analyses
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/78541caa92434ef0a576f85bf2db9c17
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_version_	1718418169414025216

Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses

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