Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques

Objectives: In breast radiotherapy, the proximity of the target to sensitive structures together with the uncertainty introduced by respiratory movement, make this treatment one of the most studied to increase its effectiveness. Dosimetric and physical variables play an important role and the study...

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Autores principales:	Xin Xin MSc, Jie Li MSc, Yanqun Zhao MSc, Pei Wang PhD, Bin Tang PhD, Xinghong Yao PhD, Xiongfei Liao MSc, Jiabao Ma MD, Lucia Clara Orlandini MSc
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7854a002745c4c868963cbda249fb55a
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spelling	oai:doaj.org-article:7854a002745c4c868963cbda249fb55a2021-12-03T00:03:32ZRetrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques1533-033810.1177/15330338211062429https://doaj.org/article/7854a002745c4c868963cbda249fb55a2021-12-01T00:00:00Zhttps://doi.org/10.1177/15330338211062429https://doaj.org/toc/1533-0338Objectives: In breast radiotherapy, the proximity of the target to sensitive structures together with the uncertainty introduced by respiratory movement, make this treatment one of the most studied to increase its effectiveness. Dosimetric and physical variables play an important role and the study of their correlation and impact on treatment is fundamental. This retrospective study aims to highlight the dosimetric differences of 2 different clinical data sets of patients receiving left-sided breast irradiation in free breathing (FB) or breath hold (BH). Methods: A total of 155 left breast carcinoma patients receiving whole-breast irradiation in FB (73 patients) and BH (82 patients) were enrolled in this study. The dosimetric parameters of the target, heart, left and right lung and right breast were evaluated and compared, and possible correlations were studied in both groups. Results: No significant difference ( P > .05) was found in the target dosimetry; a clear advantage in BH for both high and low doses received by the heart, with reductions of the dosimetric parameters between 27.1% and 100% ( P < .003); for the left lung reductions decreased with increasing dose (−22.4% and −13.4% for doses of 5 and 20 Gy, respectively, P < .003). Conclusion: Significant correlations for BH treatments were registered between the volumes of the target and left lung, and the dosimetric parameters of the heart and left lung. BH treatment brings significant dosimetric advantages to organs at risk for a wide range of patients with different anatomy, target volumes and lung capacity, with additional benefits for small-sized breasts and important lung capacity.Xin Xin MScJie Li MScYanqun Zhao MScPei Wang PhDBin Tang PhDXinghong Yao PhDXiongfei Liao MScJiabao Ma MDLucia Clara Orlandini MScSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTechnology in Cancer Research & Treatment, Vol 20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xin Xin MSc Jie Li MSc Yanqun Zhao MSc Pei Wang PhD Bin Tang PhD Xinghong Yao PhD Xiongfei Liao MSc Jiabao Ma MD Lucia Clara Orlandini MSc Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
description	Objectives: In breast radiotherapy, the proximity of the target to sensitive structures together with the uncertainty introduced by respiratory movement, make this treatment one of the most studied to increase its effectiveness. Dosimetric and physical variables play an important role and the study of their correlation and impact on treatment is fundamental. This retrospective study aims to highlight the dosimetric differences of 2 different clinical data sets of patients receiving left-sided breast irradiation in free breathing (FB) or breath hold (BH). Methods: A total of 155 left breast carcinoma patients receiving whole-breast irradiation in FB (73 patients) and BH (82 patients) were enrolled in this study. The dosimetric parameters of the target, heart, left and right lung and right breast were evaluated and compared, and possible correlations were studied in both groups. Results: No significant difference ( P > .05) was found in the target dosimetry; a clear advantage in BH for both high and low doses received by the heart, with reductions of the dosimetric parameters between 27.1% and 100% ( P < .003); for the left lung reductions decreased with increasing dose (−22.4% and −13.4% for doses of 5 and 20 Gy, respectively, P < .003). Conclusion: Significant correlations for BH treatments were registered between the volumes of the target and left lung, and the dosimetric parameters of the heart and left lung. BH treatment brings significant dosimetric advantages to organs at risk for a wide range of patients with different anatomy, target volumes and lung capacity, with additional benefits for small-sized breasts and important lung capacity.
format	article
author	Xin Xin MSc Jie Li MSc Yanqun Zhao MSc Pei Wang PhD Bin Tang PhD Xinghong Yao PhD Xiongfei Liao MSc Jiabao Ma MD Lucia Clara Orlandini MSc
author_facet	Xin Xin MSc Jie Li MSc Yanqun Zhao MSc Pei Wang PhD Bin Tang PhD Xinghong Yao PhD Xiongfei Liao MSc Jiabao Ma MD Lucia Clara Orlandini MSc
author_sort	Xin Xin MSc
title	Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
title_short	Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
title_full	Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
title_fullStr	Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
title_full_unstemmed	Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
title_sort	retrospective study on left-sided breast radiotherapy: dosimetric results and correlation with physical factors for free breathing and breath hold irradiation techniques
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/7854a002745c4c868963cbda249fb55a
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Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques

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