Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration

The bioavailability and pharmacokinetics in turkeys of cefquinome (CFQ), a broad-spectrum 4th-generation cephalosporin antibiotic, were explored after a single injection of 2 mg/kg body weight by intravenous (IV) and intramuscular (IM) routes. In a crossover design and 3-weeks washout interval, seve...

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Autores principales:	Mohamed Elbadawy, Ahmed Soliman, Amira Abugomaa, Adel Alkhedaide, Mohamed Mohamed Soliman, Mohamed Aboubakr
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cefquinome bioavailability HPLC pharmacokinetics poultry turkeys Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/78561a9fb6bb4c06ad98fd7377cc41d3
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spelling	oai:doaj.org-article:78561a9fb6bb4c06ad98fd7377cc41d32021-11-25T18:40:48ZDisposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration10.3390/pharmaceutics131118041999-4923https://doaj.org/article/78561a9fb6bb4c06ad98fd7377cc41d32021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1804https://doaj.org/toc/1999-4923The bioavailability and pharmacokinetics in turkeys of cefquinome (CFQ), a broad-spectrum 4th-generation cephalosporin antibiotic, were explored after a single injection of 2 mg/kg body weight by intravenous (IV) and intramuscular (IM) routes. In a crossover design and 3-weeks washout interval, seven turkeys were assigned for this objective. Blood samples were collected prior to and at various time intervals following each administration. The concentration of CFQ in plasma was measured using HPLC with a UV detector set at 266 nm. For pharmacokinetic analysis, non-compartmental methods have been applied. Following IV administration, the elimination half-life (t<sub>1/2ʎz</sub>), distribution volume at steady state (Vd<sub>ss</sub>), and total body clearance (Cl<sub>tot</sub>) of CFQ were 1.55 h, 0.54 L/kg, and 0.32 L/h/kg, respectively. Following the IM administration, CFQ was speedily absorbed with an absorption half-life (t<sub>1/2ab</sub>) of 0.25 h, a maximum plasma concentration (C<sub>max</sub>) of 2.71 μg/mL, attained (T<sub>max</sub>) at 0.56 h. The bioavailability (F) and in vitro plasma protein binding of CFQ were 95.56% and 11.5%, respectively. Results indicated that CFQ was speedily absorbed with a considerable bioavailability after IM administration. In conclusion, CFQ has a favorable disposition in turkeys that can guide to estimate optimum dosage regimes and eventually lead to its usage to eradicate turkey’s susceptible bacterial infections.Mohamed ElbadawyAhmed SolimanAmira AbugomaaAdel AlkhedaideMohamed Mohamed SolimanMohamed AboubakrMDPI AGarticlecefquinomebioavailabilityHPLCpharmacokineticspoultryturkeysPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1804, p 1804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cefquinome bioavailability HPLC pharmacokinetics poultry turkeys Pharmacy and materia medica RS1-441
spellingShingle	cefquinome bioavailability HPLC pharmacokinetics poultry turkeys Pharmacy and materia medica RS1-441 Mohamed Elbadawy Ahmed Soliman Amira Abugomaa Adel Alkhedaide Mohamed Mohamed Soliman Mohamed Aboubakr Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration
description	The bioavailability and pharmacokinetics in turkeys of cefquinome (CFQ), a broad-spectrum 4th-generation cephalosporin antibiotic, were explored after a single injection of 2 mg/kg body weight by intravenous (IV) and intramuscular (IM) routes. In a crossover design and 3-weeks washout interval, seven turkeys were assigned for this objective. Blood samples were collected prior to and at various time intervals following each administration. The concentration of CFQ in plasma was measured using HPLC with a UV detector set at 266 nm. For pharmacokinetic analysis, non-compartmental methods have been applied. Following IV administration, the elimination half-life (t<sub>1/2ʎz</sub>), distribution volume at steady state (Vd<sub>ss</sub>), and total body clearance (Cl<sub>tot</sub>) of CFQ were 1.55 h, 0.54 L/kg, and 0.32 L/h/kg, respectively. Following the IM administration, CFQ was speedily absorbed with an absorption half-life (t<sub>1/2ab</sub>) of 0.25 h, a maximum plasma concentration (C<sub>max</sub>) of 2.71 μg/mL, attained (T<sub>max</sub>) at 0.56 h. The bioavailability (F) and in vitro plasma protein binding of CFQ were 95.56% and 11.5%, respectively. Results indicated that CFQ was speedily absorbed with a considerable bioavailability after IM administration. In conclusion, CFQ has a favorable disposition in turkeys that can guide to estimate optimum dosage regimes and eventually lead to its usage to eradicate turkey’s susceptible bacterial infections.
format	article
author	Mohamed Elbadawy Ahmed Soliman Amira Abugomaa Adel Alkhedaide Mohamed Mohamed Soliman Mohamed Aboubakr
author_facet	Mohamed Elbadawy Ahmed Soliman Amira Abugomaa Adel Alkhedaide Mohamed Mohamed Soliman Mohamed Aboubakr
author_sort	Mohamed Elbadawy
title	Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration
title_short	Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration
title_full	Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration
title_fullStr	Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration
title_full_unstemmed	Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration
title_sort	disposition of cefquinome in turkeys (<i>meleagris gallopavo</i>) following intravenous and intramuscular administration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/78561a9fb6bb4c06ad98fd7377cc41d3
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Disposition of Cefquinome in Turkeys (<i>Meleagris gallopavo</i>) Following Intravenous and Intramuscular Administration

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