Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

Immune checkpoint blockade (ICB) therapies can unleash anti-tumour T-cell responses. Here the authors show, by integrating MHC tetramer multiplexing, mass cytometry and high-dimensional analyses, that neoantigen-specific, tumour-infiltrating T cells are highly heterogeneous and are subjected to ICB...

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Autores principales:	M. Fehlings, Y. Simoni, H. L. Penny, E. Becht, C. Y. Loh, M. M. Gubin, J. P. Ward, S. C. Wong, R. D. Schreiber, E. W. Newell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7858136795e54c05b2eaf80fa3fc40f9
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spelling	oai:doaj.org-article:7858136795e54c05b2eaf80fa3fc40f92021-12-02T14:42:39ZCheckpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells10.1038/s41467-017-00627-z2041-1723https://doaj.org/article/7858136795e54c05b2eaf80fa3fc40f92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00627-zhttps://doaj.org/toc/2041-1723Immune checkpoint blockade (ICB) therapies can unleash anti-tumour T-cell responses. Here the authors show, by integrating MHC tetramer multiplexing, mass cytometry and high-dimensional analyses, that neoantigen-specific, tumour-infiltrating T cells are highly heterogeneous and are subjected to ICB modulations.M. FehlingsY. SimoniH. L. PennyE. BechtC. Y. LohM. M. GubinJ. P. WardS. C. WongR. D. SchreiberE. W. NewellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Fehlings Y. Simoni H. L. Penny E. Becht C. Y. Loh M. M. Gubin J. P. Ward S. C. Wong R. D. Schreiber E. W. Newell Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
description	Immune checkpoint blockade (ICB) therapies can unleash anti-tumour T-cell responses. Here the authors show, by integrating MHC tetramer multiplexing, mass cytometry and high-dimensional analyses, that neoantigen-specific, tumour-infiltrating T cells are highly heterogeneous and are subjected to ICB modulations.
format	article
author	M. Fehlings Y. Simoni H. L. Penny E. Becht C. Y. Loh M. M. Gubin J. P. Ward S. C. Wong R. D. Schreiber E. W. Newell
author_facet	M. Fehlings Y. Simoni H. L. Penny E. Becht C. Y. Loh M. M. Gubin J. P. Ward S. C. Wong R. D. Schreiber E. W. Newell
author_sort	M. Fehlings
title	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_short	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_full	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_fullStr	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_full_unstemmed	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_sort	checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific cd8+ t cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7858136795e54c05b2eaf80fa3fc40f9
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Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

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