Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation

Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation

Cooperation between the ULK complex and autophagy receptors mediates targeting cargoes to autophagosomes. Here, the authors show that interactions of ULK subunit FIP200 with autophagy receptors CCPG1 and Optineurin can be regulated by phosphorylation, suggesting a general binding mode shared by auto...

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Autores principales: Zixuan Zhou, Jianping Liu, Tao Fu, Ping Wu, Chao Peng, Xinyu Gong, Yingli Wang, Mingfang Zhang, Ying Li, Yaru Wang, Xiaolong Xu, Miao Li, Lifeng Pan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/7866f28ceca14b898aab485fec664bfc
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