Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress

Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.

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Autores principales: Hyeongsun Moon, Jerry Zhu, Leanne R. Donahue, Eunju Choi, Andrew C. White
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7869f89b2952464bb4c94fa9d186093f
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spelling oai:doaj.org-article:7869f89b2952464bb4c94fa9d186093f2021-12-02T17:02:10ZKrt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress10.1038/s41467-019-10194-02041-1723https://doaj.org/article/7869f89b2952464bb4c94fa9d186093f2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10194-0https://doaj.org/toc/2041-1723Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.Hyeongsun MoonJerry ZhuLeanne R. DonahueEunju ChoiAndrew C. WhiteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyeongsun Moon
Jerry Zhu
Leanne R. Donahue
Eunju Choi
Andrew C. White
Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
description Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.
format article
author Hyeongsun Moon
Jerry Zhu
Leanne R. Donahue
Eunju Choi
Andrew C. White
author_facet Hyeongsun Moon
Jerry Zhu
Leanne R. Donahue
Eunju Choi
Andrew C. White
author_sort Hyeongsun Moon
title Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
title_short Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
title_full Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
title_fullStr Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
title_full_unstemmed Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
title_sort krt5+/krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/7869f89b2952464bb4c94fa9d186093f
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AT eunjuchoi krt5krt15foregutbasalprogenitorsgiverisetocyclooxygenase2dependenttumoursinresponsetogastricacidstress
AT andrewcwhite krt5krt15foregutbasalprogenitorsgiverisetocyclooxygenase2dependenttumoursinresponsetogastricacidstress
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