The first transmembrane region of complement component-9 acts as a brake on its self-assembly

The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target...

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Autores principales:	Bradley A. Spicer, Ruby H. P. Law, Tom T. Caradoc-Davies, Sue M. Ekkel, Charles Bayly-Jones, Siew-Siew Pang, Paul J. Conroy, Georg Ramm, Mazdak Radjainia, Hariprasad Venugopal, James C. Whisstock, Michelle A. Dunstone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/786ad92e96b04d58a33f04be085b9901
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spelling	oai:doaj.org-article:786ad92e96b04d58a33f04be085b99012021-12-02T15:33:46ZThe first transmembrane region of complement component-9 acts as a brake on its self-assembly10.1038/s41467-018-05717-02041-1723https://doaj.org/article/786ad92e96b04d58a33f04be085b99012018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05717-0https://doaj.org/toc/2041-1723The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane.Bradley A. SpicerRuby H. P. LawTom T. Caradoc-DaviesSue M. EkkelCharles Bayly-JonesSiew-Siew PangPaul J. ConroyGeorg RammMazdak RadjainiaHariprasad VenugopalJames C. WhisstockMichelle A. DunstoneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bradley A. Spicer Ruby H. P. Law Tom T. Caradoc-Davies Sue M. Ekkel Charles Bayly-Jones Siew-Siew Pang Paul J. Conroy Georg Ramm Mazdak Radjainia Hariprasad Venugopal James C. Whisstock Michelle A. Dunstone The first transmembrane region of complement component-9 acts as a brake on its self-assembly
description	The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane.
format	article
author	Bradley A. Spicer Ruby H. P. Law Tom T. Caradoc-Davies Sue M. Ekkel Charles Bayly-Jones Siew-Siew Pang Paul J. Conroy Georg Ramm Mazdak Radjainia Hariprasad Venugopal James C. Whisstock Michelle A. Dunstone
author_facet	Bradley A. Spicer Ruby H. P. Law Tom T. Caradoc-Davies Sue M. Ekkel Charles Bayly-Jones Siew-Siew Pang Paul J. Conroy Georg Ramm Mazdak Radjainia Hariprasad Venugopal James C. Whisstock Michelle A. Dunstone
author_sort	Bradley A. Spicer
title	The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_short	The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_full	The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_fullStr	The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_full_unstemmed	The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_sort	first transmembrane region of complement component-9 acts as a brake on its self-assembly
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/786ad92e96b04d58a33f04be085b9901
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The first transmembrane region of complement component-9 acts as a brake on its self-assembly

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