Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show that interaction of the MORF subunit with acylated H3...

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Autores principales:	Brianna J. Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W. Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M. Warfield, Andrew J. Kueh, Anne K. Voss, Tim Thomas, Benjamin A. Garcia, Wenshe R. Liu, Brian D. Strahl, Hidetoshi Kono, Wei Li, Xiaobing Shi, Jacques Côté, Tatiana G. Kutateladze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78758c527c604e018605e9ed73ff1cd5
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spelling	oai:doaj.org-article:78758c527c604e018605e9ed73ff1cd52021-12-02T15:35:28ZHistone H3K23-specific acetylation by MORF is coupled to H3K14 acylation10.1038/s41467-019-12551-52041-1723https://doaj.org/article/78758c527c604e018605e9ed73ff1cd52019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12551-5https://doaj.org/toc/2041-1723Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show that interaction of the MORF subunit with acylated H3K14 promotes acetylation of H3K23 by this complex to activate transcription.Brianna J. KleinSuk Min JangCatherine LachanceWenyi MiJie LyuShun SakurabaKrzysztof KrajewskiWesley W. WangSimone SidoliJiuyang LiuYi ZhangXiaolu WangBecka M. WarfieldAndrew J. KuehAnne K. VossTim ThomasBenjamin A. GarciaWenshe R. LiuBrian D. StrahlHidetoshi KonoWei LiXiaobing ShiJacques CôtéTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brianna J. Klein Suk Min Jang Catherine Lachance Wenyi Mi Jie Lyu Shun Sakuraba Krzysztof Krajewski Wesley W. Wang Simone Sidoli Jiuyang Liu Yi Zhang Xiaolu Wang Becka M. Warfield Andrew J. Kueh Anne K. Voss Tim Thomas Benjamin A. Garcia Wenshe R. Liu Brian D. Strahl Hidetoshi Kono Wei Li Xiaobing Shi Jacques Côté Tatiana G. Kutateladze Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
description	Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show that interaction of the MORF subunit with acylated H3K14 promotes acetylation of H3K23 by this complex to activate transcription.
format	article
author	Brianna J. Klein Suk Min Jang Catherine Lachance Wenyi Mi Jie Lyu Shun Sakuraba Krzysztof Krajewski Wesley W. Wang Simone Sidoli Jiuyang Liu Yi Zhang Xiaolu Wang Becka M. Warfield Andrew J. Kueh Anne K. Voss Tim Thomas Benjamin A. Garcia Wenshe R. Liu Brian D. Strahl Hidetoshi Kono Wei Li Xiaobing Shi Jacques Côté Tatiana G. Kutateladze
author_facet	Brianna J. Klein Suk Min Jang Catherine Lachance Wenyi Mi Jie Lyu Shun Sakuraba Krzysztof Krajewski Wesley W. Wang Simone Sidoli Jiuyang Liu Yi Zhang Xiaolu Wang Becka M. Warfield Andrew J. Kueh Anne K. Voss Tim Thomas Benjamin A. Garcia Wenshe R. Liu Brian D. Strahl Hidetoshi Kono Wei Li Xiaobing Shi Jacques Côté Tatiana G. Kutateladze
author_sort	Brianna J. Klein
title	Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
title_short	Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
title_full	Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
title_fullStr	Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
title_full_unstemmed	Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
title_sort	histone h3k23-specific acetylation by morf is coupled to h3k14 acylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/78758c527c604e018605e9ed73ff1cd5
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Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

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