Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder

Abstract Recent theories suggest a shift from model-based goal-directed to model-free habitual decision-making in obsessive–compulsive disorder (OCD). However, it is yet unclear, whether this shift in the decision process is heritable. We investigated 32 patients with OCD, 27 unaffected siblings (SI...

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Autores principales:	Meltem I. Kasal, Lutfullah Besiroglu, Nabi Zorlu, Nur Dikmeer, Aslıhan Bilge, Ercan Durmaz, Serap Polat, Fazil Gelal, Michael Rapp, Andreas Heinz, Miriam Sebold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/787c5ebe8fcc4a78a9a6053fcc77b624
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spelling	oai:doaj.org-article:787c5ebe8fcc4a78a9a6053fcc77b6242021-12-02T17:52:12ZFronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder10.1038/s41598-021-91179-22045-2322https://doaj.org/article/787c5ebe8fcc4a78a9a6053fcc77b6242021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91179-2https://doaj.org/toc/2045-2322Abstract Recent theories suggest a shift from model-based goal-directed to model-free habitual decision-making in obsessive–compulsive disorder (OCD). However, it is yet unclear, whether this shift in the decision process is heritable. We investigated 32 patients with OCD, 27 unaffected siblings (SIBs) and 31 healthy controls (HCs) using the two-step task. We computed behavioral and reaction time analyses and fitted a computational model to assess the balance between model-based and model-free control. 80 subjects also underwent structural imaging. We observed a significant ordered effect for the shift towards model-free control in the direction OCD > SIB > HC in our computational parameter of interest. However less directed analyses revealed no shift towards model-free control in OCDs. Nonetheless, we found evidence for reduced model-based control in OCDs compared to HCs and SIBs via 2nd stage reaction time analyses. In this measure SIBs also showed higher levels of model-based control than HCs. Across all subjects these effects were associated with the surface area of the left medial/right dorsolateral prefrontal cortex. Moreover, correlations between bilateral putamen/right caudate volumes and these effects varied as a function of group: they were negative in SIBs and OCDs, but positive in HCs. Associations between fronto-striatal regions and model-based reaction time effects point to a potential endophenotype for OCD.Meltem I. KasalLutfullah BesirogluNabi ZorluNur DikmeerAslıhan BilgeErcan DurmazSerap PolatFazil GelalMichael RappAndreas HeinzMiriam SeboldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meltem I. Kasal Lutfullah Besiroglu Nabi Zorlu Nur Dikmeer Aslıhan Bilge Ercan Durmaz Serap Polat Fazil Gelal Michael Rapp Andreas Heinz Miriam Sebold Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
description	Abstract Recent theories suggest a shift from model-based goal-directed to model-free habitual decision-making in obsessive–compulsive disorder (OCD). However, it is yet unclear, whether this shift in the decision process is heritable. We investigated 32 patients with OCD, 27 unaffected siblings (SIBs) and 31 healthy controls (HCs) using the two-step task. We computed behavioral and reaction time analyses and fitted a computational model to assess the balance between model-based and model-free control. 80 subjects also underwent structural imaging. We observed a significant ordered effect for the shift towards model-free control in the direction OCD > SIB > HC in our computational parameter of interest. However less directed analyses revealed no shift towards model-free control in OCDs. Nonetheless, we found evidence for reduced model-based control in OCDs compared to HCs and SIBs via 2nd stage reaction time analyses. In this measure SIBs also showed higher levels of model-based control than HCs. Across all subjects these effects were associated with the surface area of the left medial/right dorsolateral prefrontal cortex. Moreover, correlations between bilateral putamen/right caudate volumes and these effects varied as a function of group: they were negative in SIBs and OCDs, but positive in HCs. Associations between fronto-striatal regions and model-based reaction time effects point to a potential endophenotype for OCD.
format	article
author	Meltem I. Kasal Lutfullah Besiroglu Nabi Zorlu Nur Dikmeer Aslıhan Bilge Ercan Durmaz Serap Polat Fazil Gelal Michael Rapp Andreas Heinz Miriam Sebold
author_facet	Meltem I. Kasal Lutfullah Besiroglu Nabi Zorlu Nur Dikmeer Aslıhan Bilge Ercan Durmaz Serap Polat Fazil Gelal Michael Rapp Andreas Heinz Miriam Sebold
author_sort	Meltem I. Kasal
title	Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
title_short	Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
title_full	Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
title_fullStr	Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
title_full_unstemmed	Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
title_sort	fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/787c5ebe8fcc4a78a9a6053fcc77b624
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Fronto-striatal structures related with model-based control as an endophenotype for obsessive–compulsive disorder

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