ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection.

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Autores principales:	Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/787e1f46425144ed98d0dc92723cdac6
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spelling	oai:doaj.org-article:787e1f46425144ed98d0dc92723cdac62021-12-02T14:39:45ZZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response10.1038/s41467-018-05559-w2041-1723https://doaj.org/article/787e1f46425144ed98d0dc92723cdac62018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05559-whttps://doaj.org/toc/2041-1723cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection.Huan LianJin WeiRu ZangWen YeQing YangXia-Nan ZhangYun-Da ChenYu-Zhi FuMing-Ming HuCao-Qi LeiWei-Wei LuoShu LiHong-Bing ShuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Lian Jin Wei Ru Zang Wen Ye Qing Yang Xia-Nan Zhang Yun-Da Chen Yu-Zhi Fu Ming-Ming Hu Cao-Qi Lei Wei-Wei Luo Shu Li Hong-Bing Shu ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
description	cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection.
format	article
author	Huan Lian Jin Wei Ru Zang Wen Ye Qing Yang Xia-Nan Zhang Yun-Da Chen Yu-Zhi Fu Ming-Ming Hu Cao-Qi Lei Wei-Wei Luo Shu Li Hong-Bing Shu
author_facet	Huan Lian Jin Wei Ru Zang Wen Ye Qing Yang Xia-Nan Zhang Yun-Da Chen Yu-Zhi Fu Ming-Ming Hu Cao-Qi Lei Wei-Wei Luo Shu Li Hong-Bing Shu
author_sort	Huan Lian
title	ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
title_short	ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
title_full	ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
title_fullStr	ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
title_full_unstemmed	ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
title_sort	zcchc3 is a co-sensor of cgas for dsdna recognition in innate immune response
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/787e1f46425144ed98d0dc92723cdac6
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ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

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