Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.

<h4>Background</h4>Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cogn...

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Autores principales:	Valentina Pieramico, Roberto Esposito, Francesca Sensi, Franco Cilli, Dante Mantini, Peter A Mattei, Valerio Frazzini, Domenico Ciavardelli, Valentina Gatta, Antonio Ferretti, Gian Luca Romani, Stefano L Sensi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/787eb33cac0e4208bdd33204d07ebb40
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spelling	oai:doaj.org-article:787eb33cac0e4208bdd33204d07ebb402021-11-18T07:07:27ZCombination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.1932-620310.1371/journal.pone.0043901https://doaj.org/article/787eb33cac0e4208bdd33204d07ebb402012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22937122/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months.<h4>Methodology</h4>Neuropsychological and occupational performances were evaluated before and at the end of the training period. fMRI was used to assess effects of training on resting state network (RSN) functional connectivity using Independent Component Analysis (ICA). Effects on cortical thickness were also studied. Finally, we evaluated whether specific dopamine-related genes can affect the response to training.<h4>Principal findings</h4>Results of the study indicate that CT improves cognitive/occupational performances and reorganizes functional connectivity. Intriguingly, individuals responding to CT showed specific dopamine-related genotypes. Indeed, analysis of dopamine-related genes revealed that carriers of DRD3 ser9gly and COMT Val158Met polymorphisms had the greatest benefits from exposure to CT.<h4>Conclusions and significance</h4>Overall, our findings support the idea that exposure to a set of structured multimodal activities can be an effective strategy to counteract aging-related cognitive decline and also indicate that significant capability of functional and structural changes are maintained in the elderly.Valentina PieramicoRoberto EspositoFrancesca SensiFranco CilliDante MantiniPeter A MatteiValerio FrazziniDomenico CiavardelliValentina GattaAntonio FerrettiGian Luca RomaniStefano L SensiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43901 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valentina Pieramico Roberto Esposito Francesca Sensi Franco Cilli Dante Mantini Peter A Mattei Valerio Frazzini Domenico Ciavardelli Valentina Gatta Antonio Ferretti Gian Luca Romani Stefano L Sensi Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
description	<h4>Background</h4>Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months.<h4>Methodology</h4>Neuropsychological and occupational performances were evaluated before and at the end of the training period. fMRI was used to assess effects of training on resting state network (RSN) functional connectivity using Independent Component Analysis (ICA). Effects on cortical thickness were also studied. Finally, we evaluated whether specific dopamine-related genes can affect the response to training.<h4>Principal findings</h4>Results of the study indicate that CT improves cognitive/occupational performances and reorganizes functional connectivity. Intriguingly, individuals responding to CT showed specific dopamine-related genotypes. Indeed, analysis of dopamine-related genes revealed that carriers of DRD3 ser9gly and COMT Val158Met polymorphisms had the greatest benefits from exposure to CT.<h4>Conclusions and significance</h4>Overall, our findings support the idea that exposure to a set of structured multimodal activities can be an effective strategy to counteract aging-related cognitive decline and also indicate that significant capability of functional and structural changes are maintained in the elderly.
format	article
author	Valentina Pieramico Roberto Esposito Francesca Sensi Franco Cilli Dante Mantini Peter A Mattei Valerio Frazzini Domenico Ciavardelli Valentina Gatta Antonio Ferretti Gian Luca Romani Stefano L Sensi
author_facet	Valentina Pieramico Roberto Esposito Francesca Sensi Franco Cilli Dante Mantini Peter A Mattei Valerio Frazzini Domenico Ciavardelli Valentina Gatta Antonio Ferretti Gian Luca Romani Stefano L Sensi
author_sort	Valentina Pieramico
title	Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
title_short	Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
title_full	Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
title_fullStr	Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
title_full_unstemmed	Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
title_sort	combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/787eb33cac0e4208bdd33204d07ebb40
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Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.

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