Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex

Abstract Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexander A. Aabedi, Sofia Kakaizada, Jacob S. Young, Jasleen Kaur, Olivia Wiese, Claudia Valdivia, Saritha Krishna, Christina Weyer-Jamora, Mitchel S. Berger, Daniel H. Weissman, David Brang, Shawn L. Hervey-Jumper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/787f8768adf24befbd897315bfc96a74
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:787f8768adf24befbd897315bfc96a74
record_format	dspace
spelling	oai:doaj.org-article:787f8768adf24befbd897315bfc96a742021-12-02T16:31:14ZConvergence of heteromodal lexical retrieval in the lateral prefrontal cortex10.1038/s41598-021-85802-52045-2322https://doaj.org/article/787f8768adf24befbd897315bfc96a742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85802-5https://doaj.org/toc/2045-2322Abstract Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and divergent results emerged. The presence of a single construct for auditory and visual processes of lexical retrieval would influence cognitive rehabilitation strategies for patients with aphasia. In this study, we perform support vector regression lesion-symptom mapping using a brain tumor model to test the hypothesis that brain regions specifically involved in lexical retrieval from visual and auditory stimuli represent overlapping neural systems. We find that principal components analysis of language tasks revealed multicollinearity between picture naming, auditory naming, and a validated measure of word finding, implying the existence of redundant cognitive constructs. Nonparametric, multivariate lesion-symptom mapping across participants was used to model accuracies on each of the four language tasks. Lesions within overlapping clusters of 8,333 voxels and 21,512 voxels in the left lateral prefrontal cortex (PFC) were predictive of impaired picture naming and auditory naming, respectively. These data indicate a convergence of heteromodal lexical retrieval within the PFC.Alexander A. AabediSofia KakaizadaJacob S. YoungJasleen KaurOlivia WieseClaudia ValdiviaSaritha KrishnaChristina Weyer-JamoraMitchel S. BergerDaniel H. WeissmanDavid BrangShawn L. Hervey-JumperNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander A. Aabedi Sofia Kakaizada Jacob S. Young Jasleen Kaur Olivia Wiese Claudia Valdivia Saritha Krishna Christina Weyer-Jamora Mitchel S. Berger Daniel H. Weissman David Brang Shawn L. Hervey-Jumper Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
description	Abstract Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and divergent results emerged. The presence of a single construct for auditory and visual processes of lexical retrieval would influence cognitive rehabilitation strategies for patients with aphasia. In this study, we perform support vector regression lesion-symptom mapping using a brain tumor model to test the hypothesis that brain regions specifically involved in lexical retrieval from visual and auditory stimuli represent overlapping neural systems. We find that principal components analysis of language tasks revealed multicollinearity between picture naming, auditory naming, and a validated measure of word finding, implying the existence of redundant cognitive constructs. Nonparametric, multivariate lesion-symptom mapping across participants was used to model accuracies on each of the four language tasks. Lesions within overlapping clusters of 8,333 voxels and 21,512 voxels in the left lateral prefrontal cortex (PFC) were predictive of impaired picture naming and auditory naming, respectively. These data indicate a convergence of heteromodal lexical retrieval within the PFC.
format	article
author	Alexander A. Aabedi Sofia Kakaizada Jacob S. Young Jasleen Kaur Olivia Wiese Claudia Valdivia Saritha Krishna Christina Weyer-Jamora Mitchel S. Berger Daniel H. Weissman David Brang Shawn L. Hervey-Jumper
author_facet	Alexander A. Aabedi Sofia Kakaizada Jacob S. Young Jasleen Kaur Olivia Wiese Claudia Valdivia Saritha Krishna Christina Weyer-Jamora Mitchel S. Berger Daniel H. Weissman David Brang Shawn L. Hervey-Jumper
author_sort	Alexander A. Aabedi
title	Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
title_short	Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
title_full	Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
title_fullStr	Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
title_full_unstemmed	Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
title_sort	convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/787f8768adf24befbd897315bfc96a74
work_keys_str_mv	AT alexanderaaabedi convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT sofiakakaizada convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT jacobsyoung convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT jasleenkaur convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT oliviawiese convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT claudiavaldivia convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT sarithakrishna convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT christinaweyerjamora convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT mitchelsberger convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT danielhweissman convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT davidbrang convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex AT shawnlherveyjumper convergenceofheteromodallexicalretrievalinthelateralprefrontalcortex
_version_	1718383882396499968

Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex

Ejemplares similares