Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.

<h4>Background</h4>Waist circumference (WC) measured at one point in time is positively associated with the risk of acute myocardial infarction (MI), but the association with changes in WC (DWC) is not clear. We investigated the association between DWC and the risk of MI in middle-aged m...

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Autores principales:	Tina Landsvig Berentzen, Marianne Uhre Jakobsen, Jakob Gerhard Stegger, Jytte Halkjaer, Anne Tjønneland, Thorkild I A Sørensen, Kim Overvad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7880e76368234916bab1e7bb22929f56
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spelling	oai:doaj.org-article:7880e76368234916bab1e7bb22929f562021-11-18T07:35:40ZChanges in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.1932-620310.1371/journal.pone.0026849https://doaj.org/article/7880e76368234916bab1e7bb22929f562011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046380/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Waist circumference (WC) measured at one point in time is positively associated with the risk of acute myocardial infarction (MI), but the association with changes in WC (DWC) is not clear. We investigated the association between DWC and the risk of MI in middle-aged men and women, and evaluated the influence from concurrent changes in BMI (DBMI).<h4>Methodology/principal findings</h4>Data on 38,593 participants from the Danish Diet, Cancer and Health study was analysed. Anthropometry was assessed in 1993-97 and 1999-02. Information on fatal and non-fatal MI was obtained from National Registers. Cases were validated by review of the medical records. Hazard ratios (HR) were calculated from Cox proportional hazard models with individuals considered at risk from 1999-02 until December 30 2009. During 8.4 years of follow-up, 1,041 incident cases of MI occurred. WC was positively associated with the risk of MI, but weakly after adjustment for BMI. DWC was not associated with the risk of MI (HR per 5 cm change = 1.01 (0.95, 1.09) with adjustment for covariates, baseline WC, BMI and DBMI). Associations with DWC were not notably different in sub-groups stratified according to baseline WC or DBMI, or when individuals with MI occurring within the first years of follow-up were excluded.<h4>Conclusions/significance</h4>WC was positively associated with the risk of MI in middle-aged men and women, but changes in WC were not. These findings suggest that a reduction in WC may be an insufficient target for prevention of MI in middle-aged men and women.Tina Landsvig BerentzenMarianne Uhre JakobsenJakob Gerhard SteggerJytte HalkjaerAnne TjønnelandThorkild I A SørensenKim OvervadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26849 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tina Landsvig Berentzen Marianne Uhre Jakobsen Jakob Gerhard Stegger Jytte Halkjaer Anne Tjønneland Thorkild I A Sørensen Kim Overvad Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
description	<h4>Background</h4>Waist circumference (WC) measured at one point in time is positively associated with the risk of acute myocardial infarction (MI), but the association with changes in WC (DWC) is not clear. We investigated the association between DWC and the risk of MI in middle-aged men and women, and evaluated the influence from concurrent changes in BMI (DBMI).<h4>Methodology/principal findings</h4>Data on 38,593 participants from the Danish Diet, Cancer and Health study was analysed. Anthropometry was assessed in 1993-97 and 1999-02. Information on fatal and non-fatal MI was obtained from National Registers. Cases were validated by review of the medical records. Hazard ratios (HR) were calculated from Cox proportional hazard models with individuals considered at risk from 1999-02 until December 30 2009. During 8.4 years of follow-up, 1,041 incident cases of MI occurred. WC was positively associated with the risk of MI, but weakly after adjustment for BMI. DWC was not associated with the risk of MI (HR per 5 cm change = 1.01 (0.95, 1.09) with adjustment for covariates, baseline WC, BMI and DBMI). Associations with DWC were not notably different in sub-groups stratified according to baseline WC or DBMI, or when individuals with MI occurring within the first years of follow-up were excluded.<h4>Conclusions/significance</h4>WC was positively associated with the risk of MI in middle-aged men and women, but changes in WC were not. These findings suggest that a reduction in WC may be an insufficient target for prevention of MI in middle-aged men and women.
format	article
author	Tina Landsvig Berentzen Marianne Uhre Jakobsen Jakob Gerhard Stegger Jytte Halkjaer Anne Tjønneland Thorkild I A Sørensen Kim Overvad
author_facet	Tina Landsvig Berentzen Marianne Uhre Jakobsen Jakob Gerhard Stegger Jytte Halkjaer Anne Tjønneland Thorkild I A Sørensen Kim Overvad
author_sort	Tina Landsvig Berentzen
title	Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
title_short	Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
title_full	Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
title_fullStr	Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
title_full_unstemmed	Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
title_sort	changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/7880e76368234916bab1e7bb22929f56
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Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.

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