Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.

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Autores principales:	Marco D. Carpenter, Qiwen Hu, Allison M. Bond, Sonia I. Lombroso, Kyle S. Czarnecki, Carissa J. Lim, Hongjun Song, Mathieu E. Wimmer, R. Christopher Pierce, Elizabeth A. Heller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78819fd7dce048ceba481adca31e2868
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spelling	oai:doaj.org-article:78819fd7dce048ceba481adca31e28682021-12-02T17:32:12ZNr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes10.1038/s41467-020-14331-y2041-1723https://doaj.org/article/78819fd7dce048ceba481adca31e28682020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14331-yhttps://doaj.org/toc/2041-1723The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.Marco D. CarpenterQiwen HuAllison M. BondSonia I. LombrosoKyle S. CzarneckiCarissa J. LimHongjun SongMathieu E. WimmerR. Christopher PierceElizabeth A. HellerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco D. Carpenter Qiwen Hu Allison M. Bond Sonia I. Lombroso Kyle S. Czarnecki Carissa J. Lim Hongjun Song Mathieu E. Wimmer R. Christopher Pierce Elizabeth A. Heller Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
description	The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.
format	article
author	Marco D. Carpenter Qiwen Hu Allison M. Bond Sonia I. Lombroso Kyle S. Czarnecki Carissa J. Lim Hongjun Song Mathieu E. Wimmer R. Christopher Pierce Elizabeth A. Heller
author_facet	Marco D. Carpenter Qiwen Hu Allison M. Bond Sonia I. Lombroso Kyle S. Czarnecki Carissa J. Lim Hongjun Song Mathieu E. Wimmer R. Christopher Pierce Elizabeth A. Heller
author_sort	Marco D. Carpenter
title	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_short	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_full	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_fullStr	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_full_unstemmed	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_sort	nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/78819fd7dce048ceba481adca31e2868
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Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

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