Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.
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Autores principales: | Marco D. Carpenter, Qiwen Hu, Allison M. Bond, Sonia I. Lombroso, Kyle S. Czarnecki, Carissa J. Lim, Hongjun Song, Mathieu E. Wimmer, R. Christopher Pierce, Elizabeth A. Heller |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/78819fd7dce048ceba481adca31e2868 |
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