Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.

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Autores principales: Marco D. Carpenter, Qiwen Hu, Allison M. Bond, Sonia I. Lombroso, Kyle S. Czarnecki, Carissa J. Lim, Hongjun Song, Mathieu E. Wimmer, R. Christopher Pierce, Elizabeth A. Heller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/78819fd7dce048ceba481adca31e2868
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