Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer

Ovarian cancer (OC) is one of the deadliest gynecological malignancies worldwide and has a high mortality rate. Its dismal prognosis is closely related to late diagnosis and drug resistance. Exosomes are a novel means of intercellular communication that are involved in the genesis and development of...

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Autores principales:	Yu Zhang, Yi-Jing Wei, Yi-Fei Zhang, Hao-Wen Liu, Yin-Feng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ovarian cancer Exosomal ncRNA biomarker progression therapeutic function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/78820736a05b4723bc79fb841769294c
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spelling	oai:doaj.org-article:78820736a05b4723bc79fb841769294c2021-11-05T10:26:19ZEmerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer2234-943X10.3389/fonc.2021.765458https://doaj.org/article/78820736a05b4723bc79fb841769294c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.765458/fullhttps://doaj.org/toc/2234-943XOvarian cancer (OC) is one of the deadliest gynecological malignancies worldwide and has a high mortality rate. Its dismal prognosis is closely related to late diagnosis and drug resistance. Exosomes are a novel means of intercellular communication that are involved in the genesis and development of tumors by delivering a variety of biologically active molecules, including proteins, lipids, and nucleic acids. As an important component, noncoding RNAs (ncRNAs) are selectively enriched in exosomes and participate in the regulation of specific aspects of OC development, such as proliferation, invasion, metastasis, angiogenesis, immune escape, and treatment resistance. Therefore, strategies that specifically target exosomal ncRNAs may be attractive therapeutic options. Exosomes are readily available in almost all types of human biological fluids and are biocompatible, making them promising biomarkers of OC as well as targets for therapeutic applications. In this review, we briefly summarize the biology of exosomes, the function of exosomal ncRNAs in OC development, and their potential clinical applications as biomarkers and therapeutic tools. Ideally, exosomal ncRNAs will become increasingly valuable in the diagnosis and treatment of OC in the near future.Yu ZhangYi-Jing WeiYi-Fei ZhangHao-Wen LiuYin-Feng ZhangFrontiers Media S.A.articleovarian cancerExosomal ncRNAbiomarkerprogressiontherapeutic functionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ovarian cancer Exosomal ncRNA biomarker progression therapeutic function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ovarian cancer Exosomal ncRNA biomarker progression therapeutic function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yu Zhang Yi-Jing Wei Yi-Fei Zhang Hao-Wen Liu Yin-Feng Zhang Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer
description	Ovarian cancer (OC) is one of the deadliest gynecological malignancies worldwide and has a high mortality rate. Its dismal prognosis is closely related to late diagnosis and drug resistance. Exosomes are a novel means of intercellular communication that are involved in the genesis and development of tumors by delivering a variety of biologically active molecules, including proteins, lipids, and nucleic acids. As an important component, noncoding RNAs (ncRNAs) are selectively enriched in exosomes and participate in the regulation of specific aspects of OC development, such as proliferation, invasion, metastasis, angiogenesis, immune escape, and treatment resistance. Therefore, strategies that specifically target exosomal ncRNAs may be attractive therapeutic options. Exosomes are readily available in almost all types of human biological fluids and are biocompatible, making them promising biomarkers of OC as well as targets for therapeutic applications. In this review, we briefly summarize the biology of exosomes, the function of exosomal ncRNAs in OC development, and their potential clinical applications as biomarkers and therapeutic tools. Ideally, exosomal ncRNAs will become increasingly valuable in the diagnosis and treatment of OC in the near future.
format	article
author	Yu Zhang Yi-Jing Wei Yi-Fei Zhang Hao-Wen Liu Yin-Feng Zhang
author_facet	Yu Zhang Yi-Jing Wei Yi-Fei Zhang Hao-Wen Liu Yin-Feng Zhang
author_sort	Yu Zhang
title	Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer
title_short	Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer
title_full	Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer
title_fullStr	Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer
title_full_unstemmed	Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer
title_sort	emerging functions and clinical applications of exosomal ncrnas in ovarian cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/78820736a05b4723bc79fb841769294c
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Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer

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