Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.

<h4>Objective</h4>Formulae used to estimate glomerular filtration rate (GFR) underestimate higher GFRs and have not been well-studied in HIV-infected (HIV(+)) people; we evaluated the relationships of HIV infection and known or potential risk factors for kidney disease with directly meas...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joseph B Margolick, Lisa P Jacobson, George J Schwartz, Alison G Abraham, Annie T Darilay, Lawrence A Kingsley, Mallory D Witt, Frank J Palella
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78820db061ad4a4980c77282ca0ea275
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:78820db061ad4a4980c77282ca0ea275
record_format	dspace
spelling	oai:doaj.org-article:78820db061ad4a4980c77282ca0ea2752021-11-18T08:33:21ZFactors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.1932-620310.1371/journal.pone.0086311https://doaj.org/article/78820db061ad4a4980c77282ca0ea2752014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24516530/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Formulae used to estimate glomerular filtration rate (GFR) underestimate higher GFRs and have not been well-studied in HIV-infected (HIV(+)) people; we evaluated the relationships of HIV infection and known or potential risk factors for kidney disease with directly measured GFR and the presence of chronic kidney disease (CKD).<h4>Design</h4>Cross-sectional measurement of iohexol-based GFR (iGFR) in HIV(+) men (n = 455) receiving antiretroviral therapy, and HIV-uninfected (HIV(-)) men (n = 258) in the Multicenter AIDS Cohort Study.<h4>Methods</h4>iGFR was calculated from disappearance of infused iohexol from plasma. Determinants of GFR and the presence of CKD were compared using iGFR and GFR estimated by the CKD-Epi equation (eGFR).<h4>Results</h4>Median iGFR was higher among HIV(+) than HIV(-) men (109 vs. 106 ml/min/1.73 m(2), respectively, p = .046), and was 7 ml/min higher than median eGFR. Mean iGFR was lower in men who were older, had chronic hepatitis C virus (HCV) infection, or had a history of AIDS. Low iGFR (≤90 ml/min/1.73 m(2)) was associated with these factors and with black race. Other than age, factors associated with low iGFR were not observed with low eGFR. CKD was more common in HIV(+) than HIV(-) men; predictors of CKD were similar using iGFR and eGFR.<h4>Conclusions</h4>iGFR was higher than eGFR in this population of HIV-infected and -uninfected men who have sex with men. Presence of CKD was predicted equally well by iGFR and eGFR, but associations of chronic HCV infection and history of clinically-defined AIDS with mildly decreased GFR were seen only with iGFR.Joseph B MargolickLisa P JacobsonGeorge J SchwartzAlison G AbrahamAnnie T DarilayLawrence A KingsleyMallory D WittFrank J PalellaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e86311 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph B Margolick Lisa P Jacobson George J Schwartz Alison G Abraham Annie T Darilay Lawrence A Kingsley Mallory D Witt Frank J Palella Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.
description	<h4>Objective</h4>Formulae used to estimate glomerular filtration rate (GFR) underestimate higher GFRs and have not been well-studied in HIV-infected (HIV(+)) people; we evaluated the relationships of HIV infection and known or potential risk factors for kidney disease with directly measured GFR and the presence of chronic kidney disease (CKD).<h4>Design</h4>Cross-sectional measurement of iohexol-based GFR (iGFR) in HIV(+) men (n = 455) receiving antiretroviral therapy, and HIV-uninfected (HIV(-)) men (n = 258) in the Multicenter AIDS Cohort Study.<h4>Methods</h4>iGFR was calculated from disappearance of infused iohexol from plasma. Determinants of GFR and the presence of CKD were compared using iGFR and GFR estimated by the CKD-Epi equation (eGFR).<h4>Results</h4>Median iGFR was higher among HIV(+) than HIV(-) men (109 vs. 106 ml/min/1.73 m(2), respectively, p = .046), and was 7 ml/min higher than median eGFR. Mean iGFR was lower in men who were older, had chronic hepatitis C virus (HCV) infection, or had a history of AIDS. Low iGFR (≤90 ml/min/1.73 m(2)) was associated with these factors and with black race. Other than age, factors associated with low iGFR were not observed with low eGFR. CKD was more common in HIV(+) than HIV(-) men; predictors of CKD were similar using iGFR and eGFR.<h4>Conclusions</h4>iGFR was higher than eGFR in this population of HIV-infected and -uninfected men who have sex with men. Presence of CKD was predicted equally well by iGFR and eGFR, but associations of chronic HCV infection and history of clinically-defined AIDS with mildly decreased GFR were seen only with iGFR.
format	article
author	Joseph B Margolick Lisa P Jacobson George J Schwartz Alison G Abraham Annie T Darilay Lawrence A Kingsley Mallory D Witt Frank J Palella
author_facet	Joseph B Margolick Lisa P Jacobson George J Schwartz Alison G Abraham Annie T Darilay Lawrence A Kingsley Mallory D Witt Frank J Palella
author_sort	Joseph B Margolick
title	Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.
title_short	Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.
title_full	Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.
title_fullStr	Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.
title_full_unstemmed	Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.
title_sort	factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for hiv infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/78820db061ad4a4980c77282ca0ea275
work_keys_str_mv	AT josephbmargolick factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT lisapjacobson factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT georgejschwartz factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT alisongabraham factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT annietdarilay factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT lawrenceakingsley factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT mallorydwitt factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection AT frankjpalella factorsaffectingglomerularfiltrationrateasmeasuredbyiohexoldisappearanceinmenwithoratriskforhivinfection
_version_	1718421629556490240

Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.

Ejemplares similares