Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.

To investigate the consequences of intermittent preventive treatment (IPTp) timing on birth weight, we pooled data from two studies conducted in Benin between 2005 and 2010: a prospective cohort of 1037 pregnant women and a randomised trial comparing sulfadoxine-pyrimethamine (SP) to mefloquine in 1...

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Autores principales:	Bich-Tram Huynh, Nadine Fievet, Valérie Briand, Sophie Borgella, Achille Massougbodji, Philippe Deloron, Michel Cot
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78829c22e10248218b300002cf2af615
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spelling	oai:doaj.org-article:78829c22e10248218b300002cf2af6152021-11-18T07:22:10ZConsequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.1932-620310.1371/journal.pone.0035342https://doaj.org/article/78829c22e10248218b300002cf2af6152012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22514730/?tool=EBIhttps://doaj.org/toc/1932-6203To investigate the consequences of intermittent preventive treatment (IPTp) timing on birth weight, we pooled data from two studies conducted in Benin between 2005 and 2010: a prospective cohort of 1037 pregnant women and a randomised trial comparing sulfadoxine-pyrimethamine (SP) to mefloquine in 1601 women. A total of 1439 women (752 in the cohort and 687 in the SP arm of the randomised trial) who delivered live singletons were analysed. We showed that an early intake of the first SP dose (4 months of gestation) was associated with a lower risk of LBW compared to a late intake (6-7 months of gestation) (aOR = 0.5 p = 0.01). We also found a borderline increased risk of placental infection when the first SP dose was administered early in pregnancy (aOR = 1.7 p = 0.1). This study is the first to investigate the timing of SP administration during pregnancy. We clearly demonstrated that women who had an early intake of the first SP dose were less at risk of LBW compared to those who had a late intake. Pregnant women should be encouraged to attend antenatal visits early to get their first SP dose and a third dose of SP could be recommended to cover the whole duration of pregnancy and to avoid late infections of the placenta.Bich-Tram HuynhNadine FievetValérie BriandSophie BorgellaAchille MassougbodjiPhilippe DeloronMichel CotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35342 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bich-Tram Huynh Nadine Fievet Valérie Briand Sophie Borgella Achille Massougbodji Philippe Deloron Michel Cot Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
description	To investigate the consequences of intermittent preventive treatment (IPTp) timing on birth weight, we pooled data from two studies conducted in Benin between 2005 and 2010: a prospective cohort of 1037 pregnant women and a randomised trial comparing sulfadoxine-pyrimethamine (SP) to mefloquine in 1601 women. A total of 1439 women (752 in the cohort and 687 in the SP arm of the randomised trial) who delivered live singletons were analysed. We showed that an early intake of the first SP dose (4 months of gestation) was associated with a lower risk of LBW compared to a late intake (6-7 months of gestation) (aOR = 0.5 p = 0.01). We also found a borderline increased risk of placental infection when the first SP dose was administered early in pregnancy (aOR = 1.7 p = 0.1). This study is the first to investigate the timing of SP administration during pregnancy. We clearly demonstrated that women who had an early intake of the first SP dose were less at risk of LBW compared to those who had a late intake. Pregnant women should be encouraged to attend antenatal visits early to get their first SP dose and a third dose of SP could be recommended to cover the whole duration of pregnancy and to avoid late infections of the placenta.
format	article
author	Bich-Tram Huynh Nadine Fievet Valérie Briand Sophie Borgella Achille Massougbodji Philippe Deloron Michel Cot
author_facet	Bich-Tram Huynh Nadine Fievet Valérie Briand Sophie Borgella Achille Massougbodji Philippe Deloron Michel Cot
author_sort	Bich-Tram Huynh
title	Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
title_short	Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
title_full	Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
title_fullStr	Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
title_full_unstemmed	Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
title_sort	consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/78829c22e10248218b300002cf2af615
work_keys_str_mv	AT bichtramhuynh consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration AT nadinefievet consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration AT valeriebriand consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration AT sophieborgella consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration AT achillemassougbodji consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration AT philippedeloron consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration AT michelcot consequencesofgestationalmalariaonbirthweightfindingthebesttimeframeforintermittentpreventivetreatmentadministration
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Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.

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