Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.

<h4>Background</h4>Bacterial vaginosis (BV) is one of the most common urogenital infections among women of reproductive age that represents shifts in microbiota from Lactobacillus spp. to diverse anaerobes. The aim of our study was to evalute the diagnostic values of Gardnerella, Atopobi...

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Autores principales:	Zongxin Ling, Xia Liu, Yueqiu Luo, Xiaoxing Wu, Li Yuan, Xiaojuan Tong, Lanjuan Li, Charlie Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/788380c95da3469c9659a82d89b09657
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spelling	oai:doaj.org-article:788380c95da3469c9659a82d89b096572021-11-18T08:52:23ZAssociations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.1932-620310.1371/journal.pone.0076589https://doaj.org/article/788380c95da3469c9659a82d89b096572013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24124575/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Bacterial vaginosis (BV) is one of the most common urogenital infections among women of reproductive age that represents shifts in microbiota from Lactobacillus spp. to diverse anaerobes. The aim of our study was to evalute the diagnostic values of Gardnerella, Atopobium, Eggerthella, Megasphaera typeI, Leptotrichia/Sneathia and Prevotella, defined as a vaginal pathogenic community for BV and their associations with vaginal pH and Nugent scores.<h4>Methods and findings</h4>We investigated the vaginal pathogenic bacteria and Lactobacillus spp. with species-specific real-time quantitative PCR (qPCR) in 50 BV-positive and 50 BV-negative Chinese women of reproductive age. Relative to BV-negative subjects, a siginificant decline in Lactobacillus and an obvious increase in bacteria in the vaginal pathogenic community were observed in BV-postive subjects (P<0.05). With the exception of Megasphaera typeI, other vaginal pathogenic bacteria were highly predictable for BV with a better sensitivity and specificity. The vaginal pathogenic community was positively associated with vaginal pH and Nugent scores, while Lactobacillus spp., such as L. iners and L. crispatus was negatively associated with them (P<0.05).<h4>Conclusions</h4>Our data implied that the prevalance of vaginal pathogenic bacteria as well as the depletion of Lactobacillus was highly accurate for BV diagnosis. Vaginal microbiota shifts, especially the overgrowth of the vaginal pathogenic community, showed well diagnostic values in predicting BV. Postive correlations between those vaginal pathogenic bacteria and vaginal pH, Nugent score indicated the vaginal pathogenic community rather than a single vaginal microorganism, was participated in the onset of BV directly.Zongxin LingXia LiuYueqiu LuoXiaoxing WuLi YuanXiaojuan TongLanjuan LiCharlie XiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76589 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zongxin Ling Xia Liu Yueqiu Luo Xiaoxing Wu Li Yuan Xiaojuan Tong Lanjuan Li Charlie Xiang Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.
description	<h4>Background</h4>Bacterial vaginosis (BV) is one of the most common urogenital infections among women of reproductive age that represents shifts in microbiota from Lactobacillus spp. to diverse anaerobes. The aim of our study was to evalute the diagnostic values of Gardnerella, Atopobium, Eggerthella, Megasphaera typeI, Leptotrichia/Sneathia and Prevotella, defined as a vaginal pathogenic community for BV and their associations with vaginal pH and Nugent scores.<h4>Methods and findings</h4>We investigated the vaginal pathogenic bacteria and Lactobacillus spp. with species-specific real-time quantitative PCR (qPCR) in 50 BV-positive and 50 BV-negative Chinese women of reproductive age. Relative to BV-negative subjects, a siginificant decline in Lactobacillus and an obvious increase in bacteria in the vaginal pathogenic community were observed in BV-postive subjects (P<0.05). With the exception of Megasphaera typeI, other vaginal pathogenic bacteria were highly predictable for BV with a better sensitivity and specificity. The vaginal pathogenic community was positively associated with vaginal pH and Nugent scores, while Lactobacillus spp., such as L. iners and L. crispatus was negatively associated with them (P<0.05).<h4>Conclusions</h4>Our data implied that the prevalance of vaginal pathogenic bacteria as well as the depletion of Lactobacillus was highly accurate for BV diagnosis. Vaginal microbiota shifts, especially the overgrowth of the vaginal pathogenic community, showed well diagnostic values in predicting BV. Postive correlations between those vaginal pathogenic bacteria and vaginal pH, Nugent score indicated the vaginal pathogenic community rather than a single vaginal microorganism, was participated in the onset of BV directly.
format	article
author	Zongxin Ling Xia Liu Yueqiu Luo Xiaoxing Wu Li Yuan Xiaojuan Tong Lanjuan Li Charlie Xiang
author_facet	Zongxin Ling Xia Liu Yueqiu Luo Xiaoxing Wu Li Yuan Xiaojuan Tong Lanjuan Li Charlie Xiang
author_sort	Zongxin Ling
title	Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.
title_short	Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.
title_full	Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.
title_fullStr	Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.
title_full_unstemmed	Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.
title_sort	associations between vaginal pathogenic community and bacterial vaginosis in chinese reproductive-age women.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/788380c95da3469c9659a82d89b09657
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Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women.

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