The great escape: viral strategies to counter BST-2/tetherin.
The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST...
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Public Library of Science (PLoS)
2010
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oai:doaj.org-article:78846ea1ed90409ebeac09fc7d2382452021-12-02T20:00:41ZThe great escape: viral strategies to counter BST-2/tetherin.1553-73661553-737410.1371/journal.ppat.1000913https://doaj.org/article/78846ea1ed90409ebeac09fc7d2382452010-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20485522/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin". However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.Janet L DouglasJean K GustinKasinath ViswanathanMandana MansouriAshlee V MosesKlaus FrühPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 5, p e1000913 (2010) |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Janet L Douglas Jean K Gustin Kasinath Viswanathan Mandana Mansouri Ashlee V Moses Klaus Früh The great escape: viral strategies to counter BST-2/tetherin. |
| description |
The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin". However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses. |
| format |
article |
| author |
Janet L Douglas Jean K Gustin Kasinath Viswanathan Mandana Mansouri Ashlee V Moses Klaus Früh |
| author_facet |
Janet L Douglas Jean K Gustin Kasinath Viswanathan Mandana Mansouri Ashlee V Moses Klaus Früh |
| author_sort |
Janet L Douglas |
| title |
The great escape: viral strategies to counter BST-2/tetherin. |
| title_short |
The great escape: viral strategies to counter BST-2/tetherin. |
| title_full |
The great escape: viral strategies to counter BST-2/tetherin. |
| title_fullStr |
The great escape: viral strategies to counter BST-2/tetherin. |
| title_full_unstemmed |
The great escape: viral strategies to counter BST-2/tetherin. |
| title_sort |
great escape: viral strategies to counter bst-2/tetherin. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/78846ea1ed90409ebeac09fc7d238245 |
| work_keys_str_mv |
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