A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering

Abstract 1,2-Propanediol is an important building block as a component used in the manufacture of unsaturated polyester resin, antifreeze, biofuel, nonionic detergent, etc. Commercial production of 1,2-propanediol through microbial biosynthesis is limited by low efficiency, and chemical production o...

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Autores principales:	Yuan-ming Tao, Chong-yang Bu, Li-hua Zou, Yue-li Hu, Zhao-Juan Zheng, Jia Ouyang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	1,2-Propanediol Micro-organism Metabolic pathway Metabolic engineering Fuel TP315-360 Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/788729cf50424f33b4e3330f762ee0f6
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spelling	oai:doaj.org-article:788729cf50424f33b4e3330f762ee0f62021-11-21T12:25:37ZA comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering10.1186/s13068-021-02067-w1754-6834https://doaj.org/article/788729cf50424f33b4e3330f762ee0f62021-11-01T00:00:00Zhttps://doi.org/10.1186/s13068-021-02067-whttps://doaj.org/toc/1754-6834Abstract 1,2-Propanediol is an important building block as a component used in the manufacture of unsaturated polyester resin, antifreeze, biofuel, nonionic detergent, etc. Commercial production of 1,2-propanediol through microbial biosynthesis is limited by low efficiency, and chemical production of 1,2-propanediol requires petrochemically derived routes involving wasteful power consumption and high pollution emissions. With the development of various strategies based on metabolic engineering, a series of obstacles are expected to be overcome. This review provides an extensive overview of the progress in the microbial production of 1,2-propanediol, particularly the different micro-organisms used for 1,2-propanediol biosynthesis and microbial production pathways. In addition, outstanding challenges associated with microbial biosynthesis and feasible metabolic engineering strategies, as well as perspectives on the future microbial production of 1,2-propanediol, are discussed.Yuan-ming TaoChong-yang BuLi-hua ZouYue-li HuZhao-Juan ZhengJia OuyangBMCarticle1,2-PropanediolMicro-organismMetabolic pathwayMetabolic engineeringFuelTP315-360BiotechnologyTP248.13-248.65ENBiotechnology for Biofuels, Vol 14, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	1,2-Propanediol Micro-organism Metabolic pathway Metabolic engineering Fuel TP315-360 Biotechnology TP248.13-248.65
spellingShingle	1,2-Propanediol Micro-organism Metabolic pathway Metabolic engineering Fuel TP315-360 Biotechnology TP248.13-248.65 Yuan-ming Tao Chong-yang Bu Li-hua Zou Yue-li Hu Zhao-Juan Zheng Jia Ouyang A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
description	Abstract 1,2-Propanediol is an important building block as a component used in the manufacture of unsaturated polyester resin, antifreeze, biofuel, nonionic detergent, etc. Commercial production of 1,2-propanediol through microbial biosynthesis is limited by low efficiency, and chemical production of 1,2-propanediol requires petrochemically derived routes involving wasteful power consumption and high pollution emissions. With the development of various strategies based on metabolic engineering, a series of obstacles are expected to be overcome. This review provides an extensive overview of the progress in the microbial production of 1,2-propanediol, particularly the different micro-organisms used for 1,2-propanediol biosynthesis and microbial production pathways. In addition, outstanding challenges associated with microbial biosynthesis and feasible metabolic engineering strategies, as well as perspectives on the future microbial production of 1,2-propanediol, are discussed.
format	article
author	Yuan-ming Tao Chong-yang Bu Li-hua Zou Yue-li Hu Zhao-Juan Zheng Jia Ouyang
author_facet	Yuan-ming Tao Chong-yang Bu Li-hua Zou Yue-li Hu Zhao-Juan Zheng Jia Ouyang
author_sort	Yuan-ming Tao
title	A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
title_short	A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
title_full	A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
title_fullStr	A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
title_full_unstemmed	A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
title_sort	comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering
publisher	BMC
publishDate	2021
url	https://doaj.org/article/788729cf50424f33b4e3330f762ee0f6
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A comprehensive review on microbial production of 1,2-propanediol: micro-organisms, metabolic pathways, and metabolic engineering

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