Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown.

The rat is an important animal model in biomedical research, but gene targeting technology is not established for this species. Therefore, we aimed to produce transgenic knockdown rats using shRNA technology and pronuclear microinjection. To this purpose, we employed a tetracycline-inducible shRNA e...

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Autores principales: Katarina Kotnik, Elena Popova, Mihail Todiras, Marcelo A Mori, Natalia Alenina, Jost Seibler, Michael Bader
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/788b7714876544118cfc35c405df8dfb
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