Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.

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Autores principales:	Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D. Davidson, Ya-Jun Song, Pei-Yong Shi, Cheng-Feng Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/788df413c3c54bebaab8d4b979a10833
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spelling	oai:doaj.org-article:788df413c3c54bebaab8d4b979a108332021-12-02T16:56:40ZDevelopment of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone10.1038/s41467-018-02975-w2041-1723https://doaj.org/article/788df413c3c54bebaab8d4b979a108332018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02975-whttps://doaj.org/toc/2041-1723Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.Xiao-Feng LiHao-Long DongHong-Jiang WangXing-Yao HuangYe-Feng QiuXue JiQing YeChunfeng LiYang LiuYong-Qiang DengTao JiangGong ChengFu-Chun ZhangAndrew D. DavidsonYa-Jun SongPei-Yong ShiCheng-Feng QinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao-Feng Li Hao-Long Dong Hong-Jiang Wang Xing-Yao Huang Ye-Feng Qiu Xue Ji Qing Ye Chunfeng Li Yang Liu Yong-Qiang Deng Tao Jiang Gong Cheng Fu-Chun Zhang Andrew D. Davidson Ya-Jun Song Pei-Yong Shi Cheng-Feng Qin Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
description	Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.
format	article
author	Xiao-Feng Li Hao-Long Dong Hong-Jiang Wang Xing-Yao Huang Ye-Feng Qiu Xue Ji Qing Ye Chunfeng Li Yang Liu Yong-Qiang Deng Tao Jiang Gong Cheng Fu-Chun Zhang Andrew D. Davidson Ya-Jun Song Pei-Yong Shi Cheng-Feng Qin
author_facet	Xiao-Feng Li Hao-Long Dong Hong-Jiang Wang Xing-Yao Huang Ye-Feng Qiu Xue Ji Qing Ye Chunfeng Li Yang Liu Yong-Qiang Deng Tao Jiang Gong Cheng Fu-Chun Zhang Andrew D. Davidson Ya-Jun Song Pei-Yong Shi Cheng-Feng Qin
author_sort	Xiao-Feng Li
title	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_short	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_full	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_fullStr	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_full_unstemmed	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_sort	development of a chimeric zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/788df413c3c54bebaab8d4b979a10833
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Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

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